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Abstract
The role of rising lactate levels on substrate mobilization in exercising man is unclear.
To define the role of increasing lactate levels, D,L-sodium lactate, 6 meq/kg, was
infused into six exercising normal males. A mild work load was chosen that increased
arterial free fatty acids (FFA) and glycerol, but did not increase lactate significantly.
Infused sodium bicarbonate and sodium chloride of equal volume and osmolality served
as controls. The marked rise in arterial lactate and pyruvate to 8.8 ± 0.31 μM/ml
and 0.328 ± 0.023 μM/ml (mean ± SEM), respectively, resulted in a significant inhibition
of the increase of plasma FFA and glycerol, which occurred during the control studies.
The decreased release of these constituents could not be attributed to an “insulin
effect”, since the concentration of arterial insulin decreased during exercise and
was similar during each infusion period. It appears that an increase in plasma lactate
or pyruvate, or both, results in a direct inhibition of exercise-mediated lipolysis
in man.
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Article info
Publication history
Received:
October 1,
1973
Footnotes
☆The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Identification
Copyright
© 1974 Published by Elsevier Inc.
