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Thermogenesis in humans during overfeeding with medium-chain triglycerides

  • James O. Hill
    Correspondence
    Address reprint to James O. Hill, PhD, Department of Pediatrics, D-4130 Medical Center North, Vanderbilt University, Nashville, TN 37232.
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
  • John C. Peters
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
  • David Yang
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
  • Teresa Sharp
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
  • Mary Kaler
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
  • Naji N. Abumrad
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
  • Harry L. Greene
    Affiliations
    Clinical Nutrition Research Unit of the Department of Pediatrics, Vanderbilt University, Nashville, TN, USA

    the Department of Surgery, Vanderbilt University, Nashville, TN, USA

    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
    Search for articles by this author
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      Abstract

      To test whether excess dietary energy as medium-chain triglycerides (MCT) affects thermogenesis differently from excess dietary energy as long chain triglycerides (LCT), ten male volunteers (ages 22 to 44) were overfed (150% of estimated energy requirement) liquid formula diets containing 40% of fat as either MCT or LCT. Each patient was studied for one week on each diet in a double-blind, crossover design. Resting metabolic rate (RMR) did not change during either week of overfeeding. The thermic response to food (TEF) was greater on day 1 following a meal (1,000 kcal) containing MCT than following an isocaloric meal containing LCT (8 ± 8% v 5.8 ± .8% of ingested energy; P < .05). Moreover, the TEF observed after a 1,000 kcal meal containing MCT increased significantly to 12% (±1.3%) of ingested energy after five days of MCT overfeeding. The TEF of the 1,000 kcal meal containing LCT was unchanged by five days of LCT overfeeding (6.6 ± 1.0% of ingested energy). Energy expenditure during a 20-hour continuous enteral infusion of the diet on day 7 was also significantly higher with the MCT diet than with the LCT diet (15.7 ± 1.7% v 7.3 ± .9% of ingested energy; P < .05). Our results demonstrate that excess dietary energy as MCT stimulates thermogenesis to a greater degree than does excess energy as LCT. This increased energy expenditure, most likely due to lipogenesis in the liver, provides evidence that excess energy derived from MCT is stored with a lesser efficiency than is excess energy derived from dietary LCT.
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