This paper is only available as a PDF. To read, Please Download here.
Regression analyses were performed on individual data from our two previous clinical investigations to establish the cholesterolemic effects of individual fatty acids. Our principal objective was to determine the effects of stearic acid on plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol levels. Our second objective was to determine the variation in the cholesterolemic response of individuals to changes (Δ) in the major dietary fatty acids. The best-fitting linear regression equations relating ΔTC and ΔLDL (mg/dL) were as follows: ΔTC = 2.3 ΔC14:0 + 3.0 ΔC16:0 − 0.8 ΔC18:0 − 1.0Δpolyunsaturated fatty acids (PUFA) and ΔLDL = 2.6 ΔC14:0 + 2.9 ΔC16:0 − 0.5 ΔC18:0 − 0.7 ΔPUFA, where Δ fatty acid = change in intake expressed as percent of calories. Based on these equations, in which stearic acid has a significant, negative regression coefficient, and the other regression models analyzed, it appears that stearic acid has an independent cholesterol-lowering effect. Using the equation we developed, 75% of the actual cholesterolemic responses were within ± 10 mg/dL of the predicted response. In summary, we have developed a predictive equation (similar to those developed by both Keys and Hegsted) to estimate changes in plasma TC and LDL cholesterol levels of young men in response to changes in dietary fatty acids. However, our predictive equation separates stearic acid from the other long-chain saturated fatty acids (SFA) and indicates that it has an independent cholesterol-lowering effect. Thus, stearic acid is a unique long-chain SFA because of its effect on plasma cholesterol level.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Metabolism - Clinical and Experimental
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The effect of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: I. Effects of whole-food diets high in cocoa butter, olive oil, soybean oil, dairy butter, and milk chocolate on the plasma lipids of young men.Metabolism. 1993; 42: 121-129
- Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet.Metabolism. 1965; 14: 776-787
- Quantitative effects of dietary fat on serum cholesterol in man.Am J Clin Nutr. 1965; 17: 281-295
- Applied Linear Statistical Modes. Richard D. Irwin, Homewood, IL1985: 421-425 ed 2.
- Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels.N Engl J Med. 1988; 318: 1244-1248
Accepted: March 22, 1992
Received: October 12, 1991
☆Supported by The American Cocoa Research Institute and The Pennsylvania Agricultural Experiment Station.
© 1993 Published by Elsevier Inc.