This paper is only available as a PDF. To read, Please Download here.
Numerous studies have examined factors regulating high-density lipoprotein cholesterol (HDL-C) levels in male endurance athletes, but few studies have examined HDL-C regulation in female athletes. The present study compared lipid and lipoprotein concentrations, postheparin lipolytic activities, and the clearance rate (K2) of triglycerides following an intravenous fat infusion in 12 female distance runners (aged 33 ± 9 years, mean ± SD) and 13 sedentary women (33 ± 9 years). Runners were leaner and had greater maximum oxygen uptake values than controls. Runners also had nonsignificantly lower triglyceride (53 ± 15 v 65 ± 13 mg/dL) and higher HDL-C (62 ± 14 v 52 ± 8 mg/dL, P = .06). Lipoprotein lipase activity (LPLA) was 33% greater (P < .05) and fat clearance (K2) was 27% faster (P < .01) in the trained women, and LPLA correlated directly with K2 (r = .61) and HDL-C (r = .62) in this group (P < .05 for both). K2 was directly related to HDL-C in the athletes (r = .57, P = .06), and also when the active and sedentary women were combined (r = .43, P < .05). These results suggest that increased LPLA and enhanced plasma triglyceride clearance may contribute to the HDL-C levels of physically active premenopausal women.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Metabolism - Clinical and Experimental
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- High-density lipoprotein metabolism in runners and sedentary men.JAMA. 1984; 252: 1034-1037
- High density lipoprotein metabolism in endurance athletes and sedentary men.Circulation. 1991; 84: 140-152
- Plasma lipoprotein distributions in male and female runners.Ann NY Acad Sci. 1977; 301: 748-763
- What do muscles have to do with lipoproteins?.Circulation. 1990; 81: 1428-1430
- High density lipoprotein metabolism.J Lipid Res. 1984; 25: 1017-1058
- Prolonged exercise augments plasma triglyceride clearance.JAMA. 1986; 256: 2552-2555
- Modest changes in high-density lipoprotein concentrations and metabolism with prolonged exercise training.Circulation. 1988; 78: 25-34
- Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins.Metabolism. 1978; 27: 1661-1671
- HDL-cholesterol and other plasma lipid and lipoprotein concentrations in middleaged male and female tennis players.Metabolism. 1980; 29: 745-752
- Enzymatic determination of total serum cholesterol.Clin Chem. 1974; 20: 470-475
- Quantitative determination of serum triglycerides by the use of enzymes.Clin Chem. 1973; 19: 476-482
- Estimation of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.Clin Chem. 1972; 18: 499-502
- A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol.J Lipid Res. 1978; 19: 65-76
- Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure.J Lipid Res. 1982; 23: 1206-1223
- Abnormal concentration and anomalous distribution of apolipoprotein A-I in Tangier disease.Metabolism. 1978; 27: 165-174
- Radioimmunoassay of apolipoprotein A-II.Arteriosclerosis. 1982; 2: 160-169
- The effect of testosterone aromatization on high-density lipoprotein cholesterol level and postheparin lipolytic activity.Metabolism. 1993; 42: 446-450
- Elevated high-density lipoprotein cholesterol in endurance athletes is related to enhanced plasma triglyceride clearance.Metabolism. 1988; 37: 568-572
- The Y's Way to Physical Fitness. National Board of YMCA, Chicago, IL1982 ed 3.
- Effect of moderate physical exercise on serum lipoproteins: A controlled clinical trial with special reference to serum high-density lipoproteins.Circulation. 1979; 60: 1220-1229
- Increased plasma HDL-cholesterol and apo A-1 in sedentary middle-aged men after physical conditioning.Eur J Clin Invest. 1980; 10: 203-209
- Effect of intensive endurance training on lipoprotein profiles in young and older men.Metabolism. 1992; 41: 649-654
- The time course of alterations in plasma lipid and lipoprotein concentrations during eight weeks of endurance training.Atherosclerosis. 1980; 37: 231-238
- Differences in effects of aerobic exercise training on blood lipids in men and women.Am J Cardiol. 1989; 63: 254-256
- High density lipoprotein cholesterol and body composition of female runners.Metabolism. 1981; 30: 994-995
- High density lipoprotein2: Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase.J Clin Invest. 1987; 80: 341-347
- Intravenous fat tolerance: Correlation with very low density lipoprotein apoprotein B kinetics in man.Atherosclerosis. 1977; 26: 17-22
- Gender differences in substrate for endurance exercise.J Appl Physiol. 1990; 68: 302-308
- The relation between the levels of HDL cholesterol and the capacity for removal of triglycerides.Acta Med Scand. 1980; 208: 199-203
- Clearance of triglycerides from the circulation and its relationship to serum lipoproteins: Influence of age and sex.Scand J Clin Lab Invest. 1985; 45: 679-684
- Lipolytic enzymes and plasma lipoprotein metabolism.Ann Rev Biochem. 1980; 49: 667-693
- Acute increase in lipoprotein lipase following prolonged exercise.Metabolism. 1984; 33: 454-457
- Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action.J Clin Invest. 1989; 84: 1124-1129
- Lipoprotein metabolism influenced by training-induced changes in human skeletal muscle.J Clin Invest. 1989; 83: 558-564
- Utilization of fatty acids during exercise.in: ed 3. Biochemistry of Exercise VII. vol 21. Human Kinetics, Champaign, IL1990: 319-327
- Exercise acutely increases high density lipoprotein-cholesterol and lipoprotein lipase activity in trained and untrained men.Metabolism. 1987; 36: 188-192
- Role of hepatic-triglyceride lipase activity in the association between intrabdominal fat and plasma HDL cholesterol in obese women.Arteriosclerosis. 1989; 9: 485-492
- Plasma lipid transfer proteins.J Lipid Res. 1986; 27: 361-367
- Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation.N Engl J Med. 1990; 323: 1234-1238
- Marathon runners presented lower serum cholesterol ester transfer activity than sedentary subjects.Atherosclerosis. 1993; 101: 43-49
Accepted: September 18, 1993
Received: December 21, 1992
☆Supported by National Institutes of Health Grant No. HL-28467 and Biomedical Research Support Grant No. SO7RR05818, and by gifts from the McNulty family, the Haire family, and William Jakober.
© 1994 Published by Elsevier Inc.