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Abstract
Numerous studies have examined factors regulating high-density lipoprotein cholesterol
(HDL-C) levels in male endurance athletes, but few studies have examined HDL-C regulation
in female athletes. The present study compared lipid and lipoprotein concentrations,
postheparin lipolytic activities, and the clearance rate (K2) of triglycerides following an intravenous fat infusion in 12 female distance runners
(aged 33 ± 9 years, mean ± SD) and 13 sedentary women (33 ± 9 years). Runners were
leaner and had greater maximum oxygen uptake values than controls. Runners also had
nonsignificantly lower triglyceride (53 ± 15 v 65 ± 13 mg/dL) and higher HDL-C (62 ± 14 v 52 ± 8 mg/dL, P = .06). Lipoprotein lipase activity (LPLA) was 33% greater (P < .05) and fat clearance (K2) was 27% faster (P < .01) in the trained women, and LPLA correlated directly with K2 (r = .61) and HDL-C (r = .62) in this group (P < .05 for both). K2 was directly related to HDL-C in the athletes (r = .57, P = .06), and also when the active and sedentary women were combined (r = .43, P < .05). These results suggest that increased LPLA and enhanced plasma triglyceride
clearance may contribute to the HDL-C levels of physically active premenopausal women.
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Article info
Publication history
Accepted:
September 18,
1993
Received:
December 21,
1992
Footnotes
☆Supported by National Institutes of Health Grant No. HL-28467 and Biomedical Research Support Grant No. SO7RR05818, and by gifts from the McNulty family, the Haire family, and William Jakober.
Identification
Copyright
© 1994 Published by Elsevier Inc.
