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Abstract
Serum uric acid concentration and fractional excretion were evaluated in lean (n =
67) and obese (n = 56) girls before and during pubertal development. In both lean
and obese girls, uricemia gradually increased as puberty advanced. Obese girls were
hyperuricemic compared with lean controls (prepubertal: 184 ±83 v 130 ± 29 μmol/L, P = .007; Tanner stage II–III: 190 ± 53 v 178 ± 47 μmol/L, NS; Tanner stage IV–V: 232 ± 53 v 191 ± 53 μmol/L, P = .02). Fractional excretion of urate decreased with puberty in lean girls (6.46%
± 2.29%, 4.61% ± 2.48%, and 3.54% ± 1.84%), but not in obese subjects (3.74% ± 2.27%,
4.01% ± 1.90%, and 4.26% ± 2.26%). Urate homeostasis was similar in prepubertal obese
girls and in adolescent lean controls. We conclude that an increased serum urate concentration
occurring at puberty may be due to decreased renal clearance of urate in lean girls,
and at least in part to urate overproduction in obese subjects. Obesity may prematurely
evoke changes in urate metabolism usually observed at puberty.
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Article info
Publication history
Accepted:
August 16,
1993
Received:
March 27,
1993
Identification
Copyright
© 1994 Published by Elsevier Inc.
