Advertisement

Alcohol consumption and blood lipids in elderly coronary patients

      Abstract

      Alcohol may have a beneficial effect on coronary heart disease (CHD) that could be mediated by elevation of high-density lipoprotein cholesterol (HDLC). Data on alcohol consumption and blood lipids in coronary patients are scarce. We studied whether total ethanol intake and consumption of specific types of beverages are associated with blood lipids in older subjects with CHD. Blood lipids were measured in 1052 myocardial infarction patients aged 60 to 80 years (78% male). Intake of alcoholic beverages, total ethanol, and macronutrients was assessed by food frequency questionnaire. Seventy percent of the subjects used lipid-lowering medication. Total cholesterol was on average 5.14 mmol/L, and HDLC was on average 1.28 mmol/L. Among men, total ethanol intake was positively associated with HDLC (difference of 0.094 mmol/L for ≥15 g/d vs 0 g/d, P = .024), whereas the association with HDLC among women was not significant (difference of 0.060 mmol/L for ≥5 g/d vs 0 g/d, P = .560) after adjustment for dietary, lifestyle, and CHD risk factors. Liquor consumption was weakly positively associated with HDLC in men (P = .045). Beer consumption in men and wine consumption in women were also positively associated with HDLC, but were not significant in the fully adjusted model. In conclusion, moderate alcohol consumption may elevate HDLC in treated post–myocardial infarction patients. This may be due to ethanol and not to other beneficial substances in alcoholic beverages. Based on this finding, further research needs to be done to examine the effects of the residual substances from different types of alcoholic beverages on HDLC.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Metabolism - Clinical and Experimental
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Doll R.
        • Peto R.
        • Wheatley K.
        • et al.
        Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors.
        BMJ. 1994; 309: 911-918
        • Rimm E.B.
        • Klatsky A.
        • Grobbee D.
        • Stampfer M.J.
        Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?.
        BMJ. 1996; 312: 731-736
        • Camargo Jr, C.A.
        • Stampfer M.J.
        • Glynn R.J.
        • et al.
        Moderate alcohol consumption and risk for angina pectoris or myocardial infarction in U.S. male physicians.
        Ann Intern Med. 1997; 126: 372-375
        • Shaper A.G.
        • Wannamethee G.
        • Walker M.
        Alcohol and mortality in British men: explaining the U-shaped curve.
        Lancet. 1988; 2: 1267-1273
        • Rimm E.B.
        • Williams P.
        • Fosher K.
        • et al.
        Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors.
        BMJ. 1999; 319: 1523-1528
        • Maclure M.
        Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction.
        Epidemiol Rev. 1993; 15: 328-351
        • Stampfer M.J.
        • Colditz G.A.
        • Willett W.C.
        • et al.
        A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women.
        N Engl J Med. 1988; 319: 267-273
        • Fuchs C.S.
        • Stampfer M.J.
        • Colditz G.A.
        • et al.
        Alcohol consumption and mortality among women.
        N Engl J Med. 1995; 332: 1245-1250
        • Klatsky A.L.
        • Armstrong M.A.
        • Friedman G.D.
        Risk of cardiovascular mortality in alcohol drinkers, ex-drinkers and nondrinkers.
        Am J Cardiol. 1990; 66: 1237-1242
        • Muntwyler J.
        • Hennekens C.H.
        • Buring J.E.
        • et al.
        Mortality and light to moderate alcohol consumption after myocardial infarction.
        Lancet. 1998; 352: 1882-1885
        • Thun M.J.
        • Peto R.
        • Lopez A.D.
        • et al.
        Alcohol consumption and mortality among middle-aged and elderly U.S adults.
        N Engl J Med. 1997; 337: 1705-1714
        • Mukamal K.J.
        Alcohol use and prognosis in patients with coronary heart disease.
        Prev Cardiol. 2003; 6: 93-98
        • Gaziano J.M.
        • Buring J.E.
        • Breslow J.L.
        • et al.
        Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction.
        N Engl J Med. 1993; 329: 1829-1834
        • Sierksma A.
        • Gaag van der S.
        • Tol van A.
        • et al.
        Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers.
        Alcohol Clin Exp Res. 2002; 26: 1430-1435
        • Parker D.R.
        • McPhilips J.B.
        • Derby C.A.
        • et al.
        High-density-lipoprotein cholesterol and types of alcoholic beverages consumed among men and women.
        Am J Public Health. 1996; 86: 1022-1027
        • Langer R.D.
        • Criqui M.H.
        • Reed D.M.
        Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease.
        Circulation. 1992; 85: 910-915
        • Schröder H.
        • Ferrández O.
        • Jimenez Conde J.
        • et al.
        Cardiovascular risk profile and type of alcohol beverage consumption: a population-based study.
        Ann Nutr Metab. 2005; 49: 100-106
        • Mukamal K.J.
        • Jensen M.K.
        • Gronbaek M.
        • et al.
        Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men.
        Circulation. 2005; 112: 1406-1413
        • Sierksma A.
        • Gaag van der M.S.
        • Kluft C.
        • et al.
        Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels: a randomized, diet-controlled intervention study.
        Eur J Clin Nutr. 2002; 56: 1130-1136
        • Di Castelnuovo A.
        • Rotondo S.
        • Iacoviello L.
        • et al.
        Meta-analysis of wine and beer consumption in relation to vascular risk.
        Circulation. 2002; 105: 2836-2844
        • Contaldo F.
        • Pasanisi F.
        • Mancini M.
        Beyond the traditional interpretation of Mediterranean diet.
        Nutr Metab Cardiovasc Dis. 2003; 13: 117-119
        • Gronbaek M.
        • Deis A.
        • Sorensen T.I.
        • et al.
        Mortality associated with moderate intakes of wine, beer, or spirits.
        BMJ. 1995; 310: 1165-1169
        • Renaud S.
        • De Lorgeril M.
        Wine, alcohol, platelets, and the French paradox for coronary heart disease.
        Lancet. 1992; 339: 1523-1526
        • Criqui M.H.
        • Rigel B.L.
        Does diet or alcohol explain the French paradox?.
        Lancet. 1994; 344: 1719-1723
        • Mukamal K.J.
        • Conigrave K.M.
        • Mittleman M.A.
        • et al.
        Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men.
        N Eng J Med. 2003; 348: 109-118
        • Stichting NEVO
        NEVO tabel. Nederlands Voedingsstoffenbestand 2001.
        (NEVO table. Dutch Nutrient Database 2001) Voorlichtingsbureau voor de Voeding, Den Haag2001 (in Dutch)
        • Chobanian A.V.
        • Bakris G.L.
        • Black H.R.
        Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure.
        Hypertension. 2003; 42: 1206-1252
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of LDL cholesterol in plasma without use of preparative ultracentrifuge.
        Clin Chem. 1972; 18: 499-502
        • Rimm E.B.
        Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? Authors' reply.
        BMJ. 1996; 313: 365
        • Ruidavets J.B.
        • Ducimetiere P.
        • Arveiler D.
        • et al.
        Types of alcoholic beverages and blood lipids in a French population.
        J Epidemiol Community Health. 2002; 56: 24-28
        • Hines L.M.
        • Stampfer M.J.
        • Ma J.
        • et al.
        Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction.
        N Engl J Med. 2001; 344: 549-555
        • Kabagambe E.K.
        • Baylin A.
        • Ruiz-Narvaez E.
        • et al.
        Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica.
        Am J Clin Nutr. 2005; 82: 1336-1345
        • Suh I.
        • Shaten B.J.
        • Cutler J.A.
        • et al.
        Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. The Multiple Risk Factor Intervention Trial Research Group.
        Ann Intern Med. 1992; 116: 881-887
        • Rimm E.B.
        • Stampfer M.J.
        Wine, beer, and spirits. Are they really horses of a different color?.
        Circulation. 2002; 105: 2806-2807
        • Clevidence B.A.
        • Reichman M.E.
        • Judd J.T.
        • et al.
        Effects of alcohol consumption of lipoproteins of premenopausal women: a controlled diet study.
        Arterioscler Thromb Vasc Biol. 1995; 15: 179-184
        • Lazarus R.
        • Sparrow D.
        • Weiss S.T.
        Alcohol intake and insulin levels. The Normative Aging Study.
        Am J Epidemiol. 1997; 145: 907-916