This paper is only available as a PDF. To read, Please Download here.
Abstract
The effect of angiotensin II infusion on the renal transport of purine bases and oxypurinol
(a metabolite of allopurinol) was investigated in 5 healthy subjects who were orally
given allopurinol (300 mg) 9 hours prior to the study. Angiotensin II was intravenously
administered at 8 ng/min/kg for 2 hours. The fractional clearances of uric acid, xanthine,
and oxypurinol were significantly decreased during angiotensin II infusion; however,
that of hypoxanthine did not change. The urinary excretion levels of uric acid, xanthine,
and oxypurinol were also significantly decreased during angiotensin II infusion. These
results suggest that angiotensin II infusion affected the renal clearances of uric
acid, xanthine, and oxypurinol through direct tubular transport and/or hemodynamic
changes. Accordingly, the hypouricemic effect of allopurinol may be exaggerated in
hypertensive gout patients with an enhanced renin-angiotensin system, since an increased
biological half-life of oxypurinol is expected in these patients.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Metabolism - Clinical and ExperimentalAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
Article info
Identification
Copyright
© 2002 Published by Elsevier Inc. All rights reserved.
