This paper is only available as a PDF. To read, Please Download here.
Abstract
To clarify the longitudinal metabolic process of bone growth in children, we observed
the relationship between the level of serum osteocalcin (OC), a marker of bone metabolism,
and growth velocity in 10 prepubertal patients with congenital adrenal hyperplasia
(CAH) due to 21-hydroxylase deficiency and 9 prepubertal patients with nonendocrine
short stature (NESS), but no major hormonal abnormalities influencing bone metabolism.
Obserevations were made every 6 months over a 7-year period. In patients with CAH
who exhibited a wide variation in growth velocity during the course of the investigation,
the levels of OC fluctuated over a wide range, suggesting metabolically variable bone
growth. In contrast, in patients with NESS who exhibited a relatively stable growth
velocity, the OC level remained within a narrow range, suggesting metabolically stable
bone growth. The meaning of such divergent metabolic processes of bone growth observed
in CAH and NESS and its relationship to actual bone structure or bone intensity should
be further investigated.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Metabolism - Clinical and ExperimentalAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
Article info
Identification
Copyright
© 2002 Published by Elsevier Inc. All rights reserved.
