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Abstract
The purpose of the present study was to determine if the improvement in insulin sensitivity
following aerobic exercise training (AEX) is associated with a decline in plasma tumor
necrosis factor-alpha (TNF-[alpha ]) levels. Fourteen older hypertensive females (age,
62 [plusmn] 2 years) participated in a 6-month AEX program. Following AEX there was
a significant increase in maximal aerobic capacity (VO2max) (P = .0001), and a significant decline in systolic (P = .01) and diastolic (P = .006) blood pressure. In addition, following AEX there was a significant decline
in total body fat mass (P = .005), abdominal fat mass (P = .048), and percent body fat (P = .006). Insulin sensitivity, as assessed by the insulin-assisted frequently sampled
intravenous glucose tolerance test (FSIVGTT), increased significantly following AEX
(P = .007). Despite the increase in insulin sensitivity and the decline in body fat,
plasma TNF-[alpha ] levels were not altered by AEX (P = .223). No significant relationship existed among the changes in TNF-[alpha ] levels
and the changes insulin sensitivity or any measure of body composition following AEX.
In conclusion, in this population of older hypertensive females, AEX improved insulin
sensitivity and lowered blood pressure without a reduction in plasma TNF-[alpha ]
levels.
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Footnotes
☆T.H.R and M.D.B. are supported by an Institutional National Research Service Award (T32 AG00114: [ldquo ]Multidisciplinary Research Training in Aging[rdquo ]), M.A.S. is supported by AG00924, and D. R. D. is supported by KO1 AG000723 from the National Institutes of Health. This work was also supported by the University of Michigan Geriatrics Center, University of Michigan Claude D. Pepper Older Americans Independence Center, University of Michigan General Clinical Research Center, and the Ann Arbor Veteran Affairs-Geriatric Research, Education, and Clinical Center.
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© 2002 Published by Elsevier Inc. All rights reserved.
