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Abstract
Adiponectin is an adipocyte-derived protein, which possesses an anti-atherosclerotic
action and improves insulin sensitivity. Peroxisome proliferator-activated receptor
gamma (PPAR[gamma ]) regulates the transcription of many adipocyte-specific genes.
A Pro12Ala polymorphism has been detected in the PPAR[gamma ]2 gene, and this substitution
has been reported to reduce transactivation activity in vitro. We hypothesized that
individuals possessing this Ala12 allele may have a lower serum adiponectin level,
because of the observation that PPAR[gamma ] agonists increase the plasma adiponectin
level in humans. To test this hypothesis, we investigated the effects of the PPAR[gamma
]2 Pro12Ala polymorphism on anthropometric and metabolic parameters, including serum
adiponectin level, in 478 Japanese men and 117 women aged 30 to 65 years. There were
no homozygous subjects for the Ala12 allele of the PPAR[gamma ]2 gene in this study.
Plasma adiponectin levels were significantly lower in subjects with the Ala12 allele
in the Japanese population of both sexes, although body mass index (BMI), plasma glucose,
serum lipids, and insulin resistance index were not significantly different between
subjects with and without this polymorphism. It is suggested that the Pro12Ala polymorphism
of the PPAR[gamma ]2 gene may reduce serum adiponectin level in the Japanese population.
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Footnotes
☆Supported in part by research grants (to H.H and Y.Y) from Keio University, Tokyo, Japan.
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© 2002 Published by Elsevier Inc. All rights reserved.
