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Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus

      Abstract

      The aim of the present study was to investigate the association of serum adiponectin concentration with regional adiposity and insulin resistance in subjects with type 2 diabetes mellitus. A total of 73 Japanese men with type 2 diabetes (aged 59 ± 11 years and body mass index [BMI] 23.8 ± 3.0 kg/m2, mean ± SD) were studied. Fasting serum adiponectin and leptin concentrations were determined by radioimmunoassay. Regional adiposity was measured by abdominal computed tomography (CT) at the umbilical level, and insulin resistance was estimated by homeostasis model assessment (HOMA-R). Univariate regression analysis showed that serum adiponectin levels were negatively correlated with subcutaneous and visceral fat areas. With multivariate regression analysis, visceral fat area was a predominant determinant of serum adiponectin levels. In contrast, subcutaneous fat area was strongly associated with serum leptin concentrations. Among subcutaneous and visceral fat areas, BMI, and serum leptin levels, both subcutaneous and visceral fat areas were independently associated with HOMA-R. In another model incorporating serum adiponectin levels, serum adiponectin levels were selected as an independent determinant of HOMA-R instead of visceral fat area. In conclusion, hypoadiponectinemia was associated with visceral fat accumulation rather than subcutaneous fat depot in Japanese men with type 2 diabetes mellitus. Both subcutaneous and visceral fat accumulation contribute to insulin resistance in these subjects, and the contribution of visceral fat may be mediated, in part, by hypoadiponectinemia.
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      References

        • Arita Y.
        • Kihara S.
        • Ouchi N.
        • et al.
        Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
        Biochem Biophys Res Commun. 1999; 257: 79-83
        • Hotta K.
        • Funahashi T.
        • Arita Y.
        • et al.
        Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
        Arterioscler Thromb Vasc Biol. 2000; 20: 1595-1599
        • Weyer C.
        • Funahashi T.
        • Tanaka S.
        • et al.
        Hypoadiponectinemia in obesity and type 2 diabetes.
        J Clin Endocrinol Metab. 2001; 86: 1930-1935
        • Stefan N.
        • Vozarova B.
        • Funahashi T.
        • et al.
        Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans.
        Diabetes. 2002; 50: 1884-1888
        • Lindsay R.S.
        • Funahashi T.
        • Hanson R.L.
        • et al.
        Adiponectin and development of type 2 diabetes in the Pima Indian population.
        Lancet. 2002; 360: 57-58
        • Taniguchi A.
        • Nakai Y.
        • Sakai M.
        • et al.
        Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients.
        Metabolism. 2002; 51: 544-548
        • Nagasaka S.
        • Ishikawa S.
        • Nakamura T.
        • et al.
        Association of endogenous insulin secretion and mode of therapy with body fat and serum leptin levels in diabetic subjects.
        Metabolism. 1998; 47: 1391-1396
        • World Health Organization
        Diabetes Mellitus.
        WHO Tech Rep Ser. 1985; : 727
        • Taniguchi A.
        • Fukushima M.
        • Sakai M.
        • et al.
        Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.
        Diabetes Care. 2000; 23: 1766-1769
        • Matthews D.R.
        • Hosker J.P.
        • Rudenski A.S.
        • et al.
        Homeostasis model assessment.
        Diabetologia. 1985; 28: 412-419
        • Emoto M.
        • Nishizawa Y.
        • Maekawa K.
        • et al.
        Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas.
        Diabetes Care. 1999; 22: 818-822
        • Bonora E.
        • Targher G.
        • Alberiche M.
        • et al.
        Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Studies in subjects with various degrees of glucose tolerance and insulin sensitivity.
        Diabetes Care. 2000; 23: 57-63
        • Sjostrom L.
        • Kvist H.
        • Cederbblad A.
        • et al.
        Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium.
        Am J Physiol. 1986; 250: E736-E745
        • Kvist H.
        • Chowdhury B.
        • Sjostrom L.
        • et al.
        Adipose tissue volume determination in males by computed tomography and 40K.
        Int J Obes. 1988; 12: 249-266
        • Statnick M.A.
        • Beavers L.S.
        • Conner L.J.
        • et al.
        Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes.
        Int J Exp Diabetes Res. 2000; 1: 81-88
        • Yamauchi T.
        • Kamon J.
        • Waki H.
        • et al.
        The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
        Nat Med. 2001; 7: 941-946
        • Berg A.H.
        • Combs T.P.
        • Du X.
        • et al.
        The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.
        Nat Med. 2001; 7: 947-953
        • Maeda N.
        • Shimomura I.
        • Kishida K.
        • et al.
        Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
        Nat Med. 2002; 8: 731-737
        • Fruebis J.
        • Tsao T.-S.
        • Javorschi S.
        • et al.
        Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.
        Proc Natl Acad Sci USA. 2001; 98: 2005-2010
        • Abate N.
        • Garg A.
        • Peshock R.M.
        • et al.
        Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM.
        Diabetes. 1996; 45: 1684-1693
        • Banerji M.A.
        • Chaiken R.L.
        • Gordon D.
        • et al.
        Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?.
        Diabetes. 1995; 44: 141-146
        • Gautier J.-F.
        • Mourier A.
        • de Kerviler E.
        • et al.
        Evaluation of abdominal fat distribution in noninsulin-dependent diabetes mellitus.
        J Clin Endocrinol Metab. 1998; 83: 1306-1311
        • Banerji M.A.
        • Faridi N.
        • Atluri R.
        • et al.
        Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men.
        J Clin Endocrinol Metab. 1999; 84: 137-144
        • Kelly D.E.
        • Williams K.V.
        • Price J.C.
        • et al.
        Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus.
        J Clin Endocrinol Metab. 2001; 86: 5412-5419
        • Matsubara M.
        • Maruoka S.
        • Katayose S.
        Decreased plasma adiponectin concentrations in women with dyslipidemia.
        J Clin Endocrinol Metab. 2002; 87: 2764-2769
        • Taniguchi A.
        • Fukushima M.
        • Sakai M.
        • et al.
        The role of the body mass index and triglyceride levels in identifying insulin-sensitive and insulin-resistant variants in Japanese non-insulin-dependent diabetic patients.
        Metabolism. 2000; 49: 1001-1005
        • Nagaretani H.
        • Nakamura T.
        • Funahashi T.
        • et al.
        Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance.
        Diabetes Care. 2001; 24: 2127-2133
        • Boden G.
        Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.
        Diabetes. 1996; 45: 3-10
        • Ouchi N.
        • Kihara S.
        • Arita Y.
        • et al.
        Novel modulator for endothelial adhesion molecules.
        Circulation. 1999; 100: 2473-2476
        • Ouchi N.
        • Kihara S.
        • Arita Y.
        • et al.
        Adiponectin, adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through cAMP-dependent pathway.
        Circulation. 2000; 102: 1296-1301
        • Ouchi N.
        • Kihara S.
        • Arita Y.
        • et al.
        Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages.
        Circulation. 2001; 103: 1057-1063
        • Kondo H.
        • Shimomura I.
        • Matsukawa Y.
        • et al.
        Association of adiponectin mutation with type 2 diabetes. A candidate gene for the insulin resistance syndrome.
        Diabetes. 2002; 51: 2325-2328