Abstract
Both obesity and the polycystic ovary syndrome (PCOS) are commonly seen in women of
reproductive age. Fifty percent of all patients with PCOS are obese, and the presence
of obesity affects the clinical manifestations of PCOS. The underlying pathogenetic
mechanisms appear to involve insulin resistance and hyperinsulinemia, the magnitude
of which is greater in obese than in non-obese women with PCOS. Specific effects of
obesity on the manifestations of PCOS, underlying mechanisms of the interactions between
obesity and PCOS, and therapeutic implications of these interactions are discussed
in this article.
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Article info
Publication history
Accepted:
October 29,
2003
Received:
May 19,
2003
Footnotes
☆Supported in part by Dr Gerald G. and Dorothy Friedman and Pharmacia foundations and by Grant No. R01MH60563 from the National Institutes of Health.
Identification
Copyright
© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
