Abstract
The concurrent background level of metabolic activity may control state of vigilance,
promoting wakefulness (and hunger) when it is low, or sleep (and satiety) when it
is high. In a series of experiments, we have shown that sleep is dependent on feeding,
but only because of the metabolic consequences of food ingestion. These consequences
are sensed by glioneuronal populations (at least in the rostromedial hypothalamus),
which probably respond to channel-bound adenosine triphosphate/diphosphate turnover
(ischymetric monitoring) rather than to the binding of such downstream molecules as
adenosine and cytochrome c oxidase. This basic signal is communicated to the vigilance-controlling centers by
a cascade of peptidic and nonpeptidic messengers—messengers that promote wakefulness
and hunger, possibly via a hypometabolic action (as in the case of neuropeptide Y
or hypocretins), or somnolence and satiety, possibly via a hypermetabolic action (as
in the case of leptin or certain serotonergic agents).
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References
- Mammalian sleep, longevity and energy metabolism.Brain Behav Evol. 1974; 10: 425-470
- Dependence of sleep on nutrient's availability.Physiol Behav. 1979; 22: 735-740
- Metabolic determinants of feeding and sleep. The ischymetric hypothesis.Exp Brain Res. 1984; : 173-187
- Métabolic determinients of sleep and wakefulness: effect of metabolically active substances.Sleep Res. 1991; 20A: 82-83
- Orexins and orexin receptors : a family of hypothalamic neuropeptides and G protein–coupled receptors that regulate feeding behaviour.Cell. 1998; 92: 573-585
- Orexin A activates locus coeruleus cell firing and increases arousal in the rat.Proc Natl Acad Sci U S A. 1999; 96: 10911-10916
- Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy balance.Sleep Med Rev. 2005; 9: 231-241
- Physiological determinants of hunger, satiation and satiety.Am J Clin Nutr. 1985; 422: 1083-1092
- Relation between feeding and sleep patterns in the rat.J Comp Physiol Psychol. 1979; 93: 820-830
- Sleep and feeding patterns in the ventromedial hypothalamus lesioned rat.Physiol Behav. 1978; 21: 769-777
- Cortical activity and sleep in the rat lateral hypothalamic syndrome.Brain Res. 1980; 185: 305-321
- Intravenous infusion of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis.Am J Physiol. 1980; 238: E307-E312
- Circadian sleep and feeding patterns in the rat: possible dependence on lipogenesis and lipolysis.Am J Physiol. 1980; 228: E223-E228
- Regulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis.Ann N Y Acad Sci. 1955; 63: 15-42
- Short term and long term regulation of energy balance.in: Proceedings of the XXVI International Congress of Physiological Sciences, IUPS, New Delhi, vol X. 1974: 122-123
- Extracellular adenosine levels in neostriatum and hippocampus during rest and activity periods of rats.Neuroscience. 1996; 73: 99-107
- Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.Sleep. 2005; 28: 21-27
- Differences in brain gene expression between sleep and waking as revealed by mRNA differential display and cDNA microarray technology.J Sleep Res. 1999; 8: 44-52
- Metabolic rate and feeding balance.Ann N Y Acad Sci. 1989; 575: 86-105
- Significance of glucose, insulin and free fatty acid on the hypothalamic feeding and satiety neurons.in: Novin D. Hunger. Raven, New York (NY)1976: 145-157
- Feeding enhances extracellular lactate of local origin in the rostromedial hypothalamus but not in the cerebellum.Brain Res. 1999; 816: 84-91
- Local energy depletion in the basal forebrain increases sleep.Eur J Neurosci. 2003; 17: 863-869
- Dextrofenfluramine increases energy cost of muscular effort.Pharmacol Biochem Behav. 1986; 24: 647-655
- Satiety and sleep: the effects of bombesin.Brain Res. 1989; 478: 152-155
- Peripheral administration of bombesin increases metabolism in the rat.Physiol Behav. 1991; 49: 439-442
- Mecanisme nerveux de l'équilibre énergétique.Journ Annu Diabetol Hotel Dieu. 1976; 1: 153-156
- Chronic intracerebroventricular infusion of insulin reduced food intake and body weight in baboons.Nature. 1979; 282: 503-505
- Chronic intracerebroventricular infusion of insulin causes selective increase of slow wave sleep in rats.Brain Res. 1984; 306: 97-103
- Feeding-related insulin changes in the PVN-VMH revealed by microdialysis.Brain Res. 1995; 671: 149-158
- Intracerebroventricular injection of murine leptin enhances the postprandial metabolic rate in the rat.Brain Res. 2000; 874: 30-36
- Metabolic action of neuropeptide Y in relation to its effect on feeding.Physiol Behav. 1997; 62: 1259-1264
- The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.Endocrinology. 2000; 141: 4325-4328
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© 2006 Published by Elsevier Inc.
