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Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects

  • Jian Rong Han
    Affiliations
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA02118, USA
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  • Bin Deng
    Affiliations
    School of Public Health, Sun Yat-Sen University, Guangzhou 510080, PR China
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  • Jing Sun
    Affiliations
    School of Public Health, Sun Yat-Sen University, Guangzhou 510080, PR China
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  • Chao Gang Chen
    Affiliations
    School of Public Health, Sun Yat-Sen University, Guangzhou 510080, PR China
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  • Barbara E. Corkey
    Affiliations
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA02118, USA
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  • James L. Kirkland
    Affiliations
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA02118, USA
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  • Jing Ma
    Correspondence
    Corresponding authors. Jing Ma is to be contacted at the Department of Clinical Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, PR China. Tel.: +86 20 8733 1811; fax: +86 20 8733 0446. Wen Guo, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. Tel.: +1 617 638 8275; fax: +1 617 638 8217.
    Affiliations
    School of Public Health, Sun Yat-Sen University, Guangzhou 510080, PR China
    Search for articles by this author
  • Wen Guo
    Correspondence
    Corresponding authors. Jing Ma is to be contacted at the Department of Clinical Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, PR China. Tel.: +86 20 8733 1811; fax: +86 20 8733 0446. Wen Guo, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. Tel.: +1 617 638 8275; fax: +1 617 638 8217.
    Affiliations
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA02118, USA
    Search for articles by this author

      Abstract

      Prior studies of medium-chain triglyceride (MCT) suggest that MCT might be a useful tool for body fat mass management in obese nondiabetic humans. We now report a pilot study that tests if MCT is beneficial for moderately overweight subjects with type 2 diabetes mellitus. The study was conducted in a group of 40 free-living subjects in an urban area of China. The subjects were randomized into 2 test groups, with one given MCT and the other corn oil as control for long-chain triglycerides (LCTs). The test oil (18 g/d) was administered as part of daily food intake for 90 days. All subjects completed the study with self-reported full compliance. Body weight, waist circumference (WC), and serum samples were analyzed on days 0, 45, and 90. The MCT group showed an across-time reduction in body weight and WC, an increase in serum C-peptide concentration, a reduction in homeostasis model assessment of insulin resistance, and a decrease in serum cholesterol concentration (P < .05, repeated measures). No significant across-time difference for the above parameters was detected for the LCT group. These changes were associated with an involuntary reduction in energy intake in the MCT group (P < .05, repeated measures). A between-group comparison also shows reduced body weight, WC, and homeostasis model assessment of insulin resistance in the MCT group compared with the LCT group at the end of the study. Collectively, our results suggest a link between moderate consumption of MCT and improved risk factors in moderately overweight humans in a low-cost, free-living setting.
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