Abstract
The purpose of this study was to examine the relation between insulin sensitivity
and cardiorespiratory fitness in overweight and obese postmenopausal women. The study
population consisted of 127 overweight and obese postmenopausal women (age, 57.7 ±
4.8 years; body mass index, 32.7 ± 4.7 kg/m2). Subjects were classified by dividing the entire cohort into tertiles (T) based
on insulin sensitivity expressed per kilograms of lean body mass (LBM) (T1, <10.9;
T2, 10.9-12.9, T3, >12.9 mg/min per kilogram of LBM, respectively). Outcome measures
were body composition (dual-energy x-ray absorptiometry), visceral adipose tissue
(computed tomography), insulin sensitivity (hyperinsulinemic-euglycemic clamp), cardiorespiratory
fitness (indirect calorimetry), lower-body muscle strength (1 maximal repetition),
physical activity energy expenditure (doubly labeled water), fasting lipids, and inflammatory
profile. We found a significant positive relationship between insulin sensitivity
and cardiorespiratory fitness (r = 0.25, P = .005). Moreover, cardiorespiratory fitness was higher in the T3 group compared
to the T1 group (36.2 ± 6.1 vs 33.1 ± 5.0 mL/kg LBM per minute, respectively; P = .028). However, the difference was no longer significant after controlling for
visceral adipose tissue or muscle strength. Finally, cardiorespiratory fitness was
an independent predictor of insulin sensitivity. High levels of cardiorespiratory
fitness are associated with higher levels of insulin sensitivity in overweight and
obese postmenopausal women. Moreover, visceral adipose tissue accumulation or muscle
strength may be potential mediators of this relationship.
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Article info
Publication history
Accepted:
April 22,
2008
Received:
January 29,
2008
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
