Abstract
Sympathetic nerve activation is recognized at the adipose tissue level during cold
exposure. Adiponectin is a key protein produced by adipose tissue, but its acute modulation
remains unknown in humans exposed to cold. The aim of this study were (1) to examine
the acute effects of cold exposure on circulating adiponectin and (2) to determine
whether the changes are modulated by (a) an acute glucose ingestion as well as (b) a short-term modulation in carbohydrate (CHO) availability. Using a random crossover
design, 6 healthy men were exposed to cold for 120 minutes with ingestion of beverages
containing low (Control, 0.04 g/min) or high (High, 0.8 g/min) amounts of glucose
during the course of the experiment (study 1). In study 2, 6 healthy men were exposed
twice to cold for 120 minutes after equicaloric low-CHO diet and exercise and high-CHO
diet without exercise. Plasma adiponectin concentrations were quantified before and
during cold exposure. In study 1, adiponectin levels did not change during High, whereas
a 20% rise was observed during Control (condition × time interaction, P = .06). In study 2, adiponectin levels increased by approximately 70% during cold
exposure after both low- and high-CHO diets (effect of time, P < .05). A 120-minute period of cold exposure is accompanied by a significant increase
in adiponectin levels in young healthy men. The rise in adiponectin levels observed
during shivering is inhibited with glucose ingestion but not after diets varying in
CHO content.
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Article info
Publication history
Accepted:
November 4,
2008
Received:
July 9,
2008
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
