Abstract
Metabolic syndrome (MS) is associated with chronic kidney disease (CKD). The objective
of this study is to examine the association between obesity and MS-related CKD in
nondiabetic, nonhypertensive Korean adults. Korea National Health and Nutrition Examination
Survey III data from 3771 nondiabetic, nonhypertensive Koreans were analyzed. Metabolic syndrome was defined according to the National Cholesterol Education Program–Adult Treatment
Panel III, and CKD was diagnosed at an estimated glomerular filtration rate less than
60 mL/(min 1.73m2). The crude and multivariate-adjusted odds ratios (ORs) of CKD associated with MS
and its individual components were calculated using logistic regression models in
a study population stratified by obesity. The prevalence of MS and CKD was 13.4% and
3.2%, respectively. The association between MS and CKD was significant in obese (OR,
2.91; 95% confidence interval [CI] = 1.34-6.34), but not nonobese (OR, 1.38; 95% CI
= 0.60-3.17), subjects. In obese subjects, impaired fasting glucose (OR, 2.47; 95%
CI = 1.10-5.57) and high triglyceride levels (OR, 2.42; 95% CI = 1.01-5.83) were risk
factors for CKD, whereas no components were significantly associated with CKD in nonobese
subjects. Our findings suggest that even in nondiabetic, nonhypertensive Korean adults,
early detection and prevention of CKD in obese subjects with MS are critical.
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Article info
Publication history
Published online: July 17, 2009
Accepted:
May 29,
2009
Received:
October 6,
2008
Identification
Copyright
© 2009 Published by Elsevier Inc.
