Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome

      Abstract

      This study was undertaken to determine whether grape seed extracts (GSE) that contain powerful vasodilator phenolic compounds lower blood pressure in subjects with the metabolic syndrome. The subjects were randomized into 3 groups—(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per day—and treated for 4 weeks. Serum lipids and blood glucose were measured at the beginning of the study and at the end. Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compared with placebo. There were no significant changes in serum lipids or blood glucose values. These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.
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      References

        • Cishek M.B.
        • Galloway M.T.
        • Karim M.
        • et al.
        Effect of red wine on endothelium-dependent relaxation in rabbits.
        Clin Sci (Lond). 1997; 97: 507-511
        • De Lorgeril M.
        • Salen P.
        • Paillard F.
        • et al.
        Mediterranean diet and the French paradox: two distinct biogeographic concepts for one consolidated scientific theory on the role of nutrition in coronary artery disease.
        Cardiovasc Res. 2002; 54: 503-515
        • Edirisinghe I.
        • Burton-Freeman B.
        • Kappagoda T.
        The mechanism of the endothelium dependent relaxation evoked by a grape seed extract.
        Clin Sci (Lond). 2008; 114: 331-337
        • Wallerath T.
        • Li H.
        • Gödtel-Ambrust U.
        • et al.
        Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase.
        Circulation. 2002; 106: 1652-1658
        • Ndiaye M.
        • Chataigneau M.
        • Lobysheva I.
        • et al.
        Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery.
        FASEB J. 2004; 19: 455-457
        • López-Sepúlveda R.
        • Jiménez R.
        • Romero M.
        • et al.
        Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats.
        Hypertension. 2008; 51: 1088-1095
      1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III).
        JAMA. 2001; 285: 2486-2497
        • Chobanian A.V.
        • Bakris G.L.
        • Black H.R.
        • et al.
        Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
        Hypertension. 2003; 42: 1206-1252
        • Suzuki T.
        • Hirata K.
        • Elkind M.S.
        • et al.
        Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the Northern Manhattan Study (NOMAS).
        Am Heart J. 2008; 156: 405-410
        • Anter E.
        • Keaney Jr, J.F.
        Oxidative stress, antioxidants, and endothelial function.
        Curr Med Chem. 2004; 11: 1093-1104
        • Leifert W.R.
        • Abeywardena M.Y.
        Cardioprotective actions of grape polyphenols.
        Nutr Res. 2008; 28: 729-737
        • Gu L.
        • House S.E.
        • Rooney L.W.
        • et al.
        Sorghum extrusion increases bioavailability of catechins in weanling pigs.
        J Agric Food Chem. 2008; 56: 1283-1288
        • Ward N.C.
        • Hodgson J.M.
        • Croft K.D.
        • et al.
        The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial.
        J Hypertens. 2005; 23: 427-434
        • Grundy S.M.
        • Brewer Jr, H.B.
        • Cleeman J.I.
        • et al.
        American Heart Association, National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.
        Circulation. 2004; 109: 433-438
        • Malik S.
        • Wong N.D.
        • Franklin S.S.
        • et al.
        Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults.
        Circulation. 2004; 110: 1245-1250
        • Laaksonen D.E.
        • Lakka H.M.
        • Niskanen L.K.
        • et al.
        Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study.
        Am J Epidemiol. 2002; 156: 1070-1077
        • Sigurdardottir V.
        • Fagerberg B.
        • Hulthe J.
        Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58 year old men (AIR study).
        J. Internal Med. 2002; 252: 440-447
        • Holvoet P.
        • Vanhaecke J.
        • Janssens S.
        • et al.
        Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease.
        Circulation. 1998; 98: 1487-1494