Editorial| Volume 59, SUPPLEMENT 1, S1, October 2010

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      This supplement constitutes the sixth Annals of the Collège International de Recherche Servier (CIRS) and arises out of a 4-day symposium on Pain organized by CIRS in Quebec City, Canada, in September 2009. Since 2001, the proceedings of 5 earlier Annals, covering Stress, Aging, Depression, Sleep, and Early Life Development and Health: Impact on Later Life, have been published successively as Metabolism Supplements. All this has been accomplished during CIRS's first 10 years of operation.
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