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Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: A pilot study

      Abstract

      Evidence suggests that ginger consumption has anti-inflammatory, anti-hypertensive, glucose-sensitizing, and stimulatory effects on the gastrointestinal tract. This study assessed the effects of a hot ginger beverage on energy expenditure, feelings of appetite and satiety and metabolic risk factors in overweight men. Ten men, age 39.1±3.3 y and body mass index (BMI) 27.2±0.3 kg/m2, participated in this randomized crossover study. Resting state energy expenditure was measured using indirect calorimetry and for 6 h after consumption of a breakfast meal with or without 2 g ginger powder dissolved in a hot water beverage. Subjective feelings of satiety were assessed hourly using visual analog scales (VAS) and blood samples were taken fasted and for 3 h after breakfast consumption. There was no significant effect of ginger on total resting energy expenditure (P=.43) or respiratory quotient (P=.41). There was a significant effect of ginger on thermic effect of food (ginger vs control=42.7±21.4 kcal/d, P=.049) but the area under the curve was not different (P=.43). VAS ratings showed lower hunger (P=.002), lower prospective food intake (P=.004) and greater fullness (P=.064) with ginger consumption versus control. There were no effects of ginger on glucose, insulin, lipids, or inflammatory markers. The results, showing enhanced thermogenesis and reduced feelings of hunger with ginger consumption, suggest a potential role of ginger in weight management. Additional studies are necessary to confirm these findings.

      Abbreviations:

      EE (energy expenditure), PYY (peptide YY), RMR (resting metabolic rate), RQ (respiratory quotient), TEF (thermic effect of food), TG (triglycerides), VAS (visual analog scale)

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      References

        • Schmidt B.
        • Ribnicky D.M.
        • Poulev A.
        • Logendra S.
        • Cefalu W.T.
        • Raskin I.
        A natural history of botanical therapeutics.
        Metabolism. 2008; 57: S3-S9
        • Zick S.M.
        • Djuric Z.
        • Ruffin M.T.
        • Litzinger A.J.
        • Normolle D.P.
        • Alrawi S.
        • et al.
        Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects.
        Cancer Epidemiol Biomarkers Prev. 2008; 17: 1930-1936
        • Liu L.
        • Simon S.A.
        Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells.
        J Neurophysiol. 1996; 76: 1858-1869
        • Nammi S.
        • Sreemantula S.
        • Roufogalis B.D.
        Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats.
        Basic Clin Pharmacol Toxicol. 2009; 104: 366-373
        • Afzal M.
        • Al-Hadidi D.
        • Menon M.
        • Pesek J.
        • Dhami M.S.
        Ginger: an ethnomedical, chemical and pharmacological review.
        Drug Metabol Drug Interact. 2001; 18: 159-190
        • Al-Amin Z.M.
        • Thomson M.
        • Al-Qattan K.K.
        • Peltonen-Shalaby R.
        • Ali M.
        Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats.
        Br J Nutr. 2006; 96: 660-666
        • Goyal R.K.
        • Kadnur S.V.
        Beneficial effects of Zingiber officinale on gold thioglucose induced obesity.
        Fitoterapia. 2006; 77: 160-163
        • Chrubasik S.
        • Pittler M.H.
        • Roufogalis B.D.
        Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles.
        Phytomedicine. 2005; 12: 684-701
        • Prakash U.N.
        • Srinivasan K.
        Fat digestion and absorption in spice-pretreated rats.
        J Sci Food Agric. 2012; 92: 503-510
        • Okamoto M.
        • Irii H.
        • Tahara Y.
        • Ishii H.
        • Hirao A.
        • Udagawa H.
        • et al.
        Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet.
        J Med Chem. 2011; 54: 6295-6304
        • Dedov V.N.
        • Tran V.H.
        • Duke C.C.
        • Connor M.
        • Christie M.J.
        • Mandadi S.
        • et al.
        Gingerols: a novel class of vanilloid receptor (VR1) agonists.
        Br J Pharmacol. 2002; 137: 793-798
        • Iwasaki Y.
        • Morita A.
        • Iwasawa T.
        • Kobata K.
        • Sekiwa Y.
        • Morimitsu Y.
        • et al.
        A nonpungent component of steamed ginger—[10]-shogaol—increases adrenaline secretion via the activation of TRPV1.
        Nutr Neurosci. 2006; 9: 169-178
        • Hursel R.
        • Westerterp-Plantenga M.S.
        Thermogenic ingredients and body weight regulation.
        Int J Obes (Lond). 2010; 34: 659-669
        • Henry C.J.
        • Piggott S.M.
        Effect of ginger on metabolic rate.
        Hum Nutr Clin Nutr. 1987; 41: 89-92
        • Kissileff H.R.
        • Wentzlaff T.H.
        • Guss J.L.
        • Walsh B.T.
        • Devlin M.J.
        • Thornton J.C.
        A direct measure of satiety disturbance in patients with bulimia nervosa.
        Physiol Behav. 1996; 60: 1077-1085
        • Cohen J.
        2nd ed. Statistical power analysis for the behavioral sciences. Lawrence Erlbaum Associates, Hillsdale, NJ1988
        • Suekawa M.
        • Ishige A.
        • Yuasa K.
        • Sudo K.
        • Aburada M.
        • Hosoya E.
        Pharmacological studies on ginger. I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol.
        J Pharmacobiodyn. 1984; 7: 836-848
        • Hoffmann D.
        Medical herbalism: the science and practice of herbal medicine.
        Rochester, VT, Healing Arts Press2003
        • Henry C.J.
        • Emery B.
        Effect of spiced food on metabolic rate.
        Hum Nutr Clin Nutr. 1986; 40: 165-168
        • Kawada T.
        • Sakabe S.
        • Watanabe T.
        • Yamamoto M.
        • Iwai K.
        Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthetized rats.
        Proc Soc Exp Biol Med. 1988; 188: 229-233
        • Eldershaw T.P.
        • Colquhoun E.Q.
        • Dora K.A.
        • Peng Z.C.
        • Clark M.G.
        Pungent principles of ginger (Zingiber officinale) are thermogenic in the perfused rat hindlimb.
        Int J Obes Relat Metab Disord. 1992; 16: 755-763
        • Drazen D.L.
        • Vahl T.P.
        • D'Alessio D.A.
        • Seeley R.J.
        • Woods S.C.
        Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status.
        Endocrinology. 2006; 147: 23-30
        • Ueki S.
        • Miyoshi M.
        • Shido O.
        • Hasegawa J.
        • Watanabe T.
        Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate.
        Eur J Pharmacol. 2008; 584: 87-92
        • Wadikar D.D.
        • Premavalli K.S.
        Appetizer administration stimulates food consumption, weight gain and leptin levels in male Wistar rats.
        Appetite. 2011; 57: 131-133
        • Zakaria Z.A.
        • Mohamad A.S.
        • Chear C.T.
        • Wong Y.Y.
        • Israf D.A.
        • Sulaiman M.R.
        Antiinflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems.
        Med Princ Pract. 2010; 19: 287-294
        • Skulas-Ray A.C.
        • Kris-Etherton P.M.
        • Teeter D.L.
        • Chen C.Y.
        • Vanden Heuvel J.P.
        • West S.G.
        A high antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men.
        J Nutr. 2011; 141: 1451-1457
        • Smeets A.J.
        • Westerterp-Plantenga M.S.
        The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety.
        Eur J Nutr. 2009; 48: 229-234