Abstract
MicroRNAs are structural components of an epigenetic mechanism of post-transcriptional
regulation of messenger RNA translation. Recently, there is significant interest in
the application of microRNA as a blood-based biomarker of underlying physiologic conditions,
and the therapeutic administration of microRNA inhibitors and mimics. The purpose
of this review is to describe the current body of knowledge on microRNA regulation
of genes involved in lipid metabolism, and to introduce the role of microRNA in development
and progression of atherosclerosis.
Abbreviations:
miR (microRNA), mRNA (messenger RNA), RNA (ribosomal nucleic acid), pri-miR (primary microRNA), DGCR8 (DiGeorge syndrome critical region gene 8), RISC (ribonucleoprotein miR-induced silencing complex), LDL-c (low density lipoprotein cholesterol), HDL-c (high density lipoprotein cholesterol), SREBF (Sterol Regulatory Binding Element Factor), ABCA1 (Adenosine Triphosphate Binding Cassette Transporter)Keywords
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Article info
Publication history
Published online: May 21, 2012
Accepted:
April 5,
2012
Received:
December 19,
2011
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
