Clinical Science| Volume 61, ISSUE 12, P1747-1755, December 2012

Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study



      Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort.


      Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n=3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension.


      During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11–2.02, P for trend .004) for BPP and 1.68 (1.23–2.04, P for trend .028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity.


      We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.


      BMI (body mass index), BPP (blood pressure progression), CI (confidence interval), DBP (diastolic blood pressure), eGFR (estimated glomerular filtration rate), HDL-C (high-density lipoprotein cholesterol), HR (hazard ratio), JNC VI (the Sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure), LDL-C (low-density lipoprotein cholesterol), MDRD (Modification of Diet in Renal Disease), NHIS (the National Health Interview Survey), SBP (systolic blood pressure), SD (standard deviation), SUA (serum uric acid), TwSHHH (the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia)


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