Abstract
Objective
Little is known about serum uric acid (SUA) role for hypertension in the Asian countries
with low cardiovascular events. We aimed to explore the relationship in a comprehensive
Chinese cohort.
Methods
Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia,
and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment
in 2002 (n=3257) were evaluated for the longitudinal association between baseline SUA and blood
pressure progression (BPP) and incident hypertension.
Results
During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression
to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension.
In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals
(CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11–2.02, P for trend .004) for BPP and 1.68 (1.23–2.04, P for trend .028) for incident hypertension. The positively graded relationships between
SUA concentration and blood pressure outcomes were observed in both males and females.
More interestingly, a statistically significant trend for increasing risk of BPP and
incident hypertension across SUA quartiles was most pronounced in participants with
abdominal obesity.
Conclusion
We concluded that SUA level was an independent predictor of blood pressure progression
and incident hypertension in a Chinese population.
Abbreviations:
BMI (body mass index), BPP (blood pressure progression), CI (confidence interval), DBP (diastolic blood pressure), eGFR (estimated glomerular filtration rate), HDL-C (high-density lipoprotein cholesterol), HR (hazard ratio), JNC VI (the Sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure), LDL-C (low-density lipoprotein cholesterol), MDRD (Modification of Diet in Renal Disease), NHIS (the National Health Interview Survey), SBP (systolic blood pressure), SD (standard deviation), SUA (serum uric acid), TwSHHH (the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia)Keywords
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Article info
Publication history
Published online: June 01, 2012
Accepted:
November 8,
2011
Received:
September 7,
2011
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
