Abstract
Objective
Evidence from pre-clinical studies suggests inhibition of stearoyl co-A desaturase-1
(SCD-1) activity improves insulin sensitivity. Translation of these findings to humans
remains less defined. The purpose of this research was to evaluate the association
between different measures of SCD-1 activity and incident diabetes in a large, prospective
human study.
Methods
In 2738 white participants (aged 45–64 yrs, 47% men) who were free of diabetes at baseline, SCD-1 activity was estimated
at baseline by plasma fatty acid ratios in cholesterol esters (SCD16c=16:1n-7/16:0, SCD18c =18:1n-9/18:0) and in phospholipids (SCD16p=16:1n-7/16:0, SCD18p=18:1n-9/18:0). Incident diabetes was ascertained during 3 follow-up visits. Cox proportional
hazards regression was used to determine the association between estimated SCD-1 activity
and incident diabetes.
Results
During follow-up (mean 8.0±SE 2.1 years), 207 (7.6%) participants developed diabetes. After adjusting for age and sex,
higher SCD16c, higher SCD16p, and lower SCD18p were significantly associated with
incident diabetes. After additional adjustment for education, parental history of
diabetes, smoking, dietary intake (carbohydrate, fiber, saturated/monounsaturated/polyunsaturated
fat), alcohol use, physical activity, body mass index (BMI), waist-hip ratio, blood
pressure, and lipid composition – only SCD16c remained significantly associated with
incident diabetes (Hazard Ratio=1.1 linearly across decreasing quintiles, 95% CI 1.01-1.30; p =0.03) which remained nominally associated after adjusting for insulin resistance (p=0.05).
Conclusions
In a large community-based prospective cohort study, the estimate of SCD-1 activity
by SCD16c had the strongest association with incident diabetes. Refinement of SCD-1
measurement and replication of its association with incident diabetes in an independent
cohort is recommended.
Abbreviations:
ARIC (Atherosclerosis Risk in Communities), 16:0 (palmitic acid), 16:1n-7 (palmitoleic acid), 18:0 (stearic acid), 18:1n-9 (oleic acid), SCD-1 (stearoyl co-A desaturase-1), SCD16c (16:1n-7/16:0 ratio in plasma cholesterol esters), SCD16p (16:1n-7/16:0 ratio in plasma phospholipids), SCD18c (18:1n-9/18:0 ratio in plasma cholesterol esters), SCD18p (18:1n-9/18:0 ratio in plasma phospholipids)Keywords
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Article info
Publication history
Published online: July 23, 2012
Accepted:
June 18,
2012
Received:
February 15,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
