Abstract
Objective
Insulin resistance (IR) is associated with low adiponectin and elevated high sensitivity
C-reactive protein (hsCRP). Osteoprotegerin (OPG) has been shown to be elevated in
type 2 diabetes, but whether it reflects underlying IR is unclear. We aimed to compare
the ability of serum OPG with adiponectin and hsCRP to act as a marker for IR in individuals
with normal and abnormal glucose tolerance.
Materials/methods
115 men underwent a 75 g oral glucose tolerance test. OPG, hsCRP and adiponectin were measured using ELISA.
IR was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR).
Results
Men with abnormal glucose tolerance (n=38) were older (58.3±11.2 vs 47.3±11.4 years, P<.001), had higher body mass index (BMI) (31.1±2.9 vs 27.9±3.2 kg/m2, P<.001) and were more insulin resistant (median (I.Q.) HOMA-IR 5.88 (3.38) vs 1.13 (1.14),
P<.001) than those with normal glucose tolerance (n=77). After adjustment for age and BMI, OPG (6.28 (2.32) vs 5.16 (1.86) pmol/L, P<.001) and hsCRP (2.07 (5.47) vs 0.78 (1.05) mg/L, P<.001) were higher and adiponectin (3.02±1.17 vs 4.78±2.38 μg/mL, P<.001) was lower in those with AGT. After adjustment for age and BMI, adiponectin (r=−0.317, P<.001) and hsCRP (r=0.318, P<.001), but not OPG (r=0.126, P=.196) correlated with HOMA-IR. On multiple linear regression analysis, adiponectin
and hsCRP but not OPG were independent predictors of HOMA-IR.
Conclusions
OPG is higher in individuals with abnormal glucose tolerance, but unlike adiponectin
and hsCRP, does not correlate with HOMA-IR, suggesting its elevation within this cohort
of individuals is due to factors other than insulin resistance.
Abbreviations:
hsCRP (high sensitivity C-reactive protein), OPG (Osteoprotegerin), HOMA-IR (homeostatic model assessment of insulin resistance), IR (insulin resistance), NGT (normal glucose), OGTT (oral glucose tolerance test), AUC (Area under the curve), ACE (angiotensin converting enzyme), ARB (inhibitor, angiotensin receptor blocker)Keywords
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Article info
Publication history
Published online: July 30, 2012
Accepted:
June 18,
2012
Received:
October 2,
2011
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
