Abstract
Objectives
Evidence for a causal relationship between sleep-loss and metabolism is derived primarily
from short-term sleep deprivation studies in the laboratory. The objective of this
study was to investigate whether small changes in sleep duration over a three week
period while participants are living in their normal environment lead to changes in
insulin sensitivity and other metabolic parameters.
Methods
Nineteen healthy, young, normal-weight men were randomised to either sleep restriction
(habitual bedtime minus 1.5 h) or a control condition (habitual bedtime) for three weeks. Weekly assessments of
insulin sensitivity by hyperinsulinaemic–euglycaemic clamp, anthropometry, vascular
function, leptin and adiponectin were made. Sleep was assessed continuously using
actigraphy and diaries.
Results
Assessment of sleep by actigraphy confirmed that the intervention reduced daily sleep
duration by 01:19 ± 00:15 (SE; p<0.001). Sleep restriction led to changes in insulin sensitivity, body weight and plasma
concentrations of leptin which varied during the three week period. There was no effect
on plasma adiponectin or vascular function.
Conclusions
Even minor reductions in sleep duration lead to changes in insulin sensitivity, body
weight and other metabolic parameters which vary during the exposure period. Larger
and longer longitudinal studies of sleep restriction and sleep extension are warranted.
Abbreviations:
T2DM (Type 2 Diabetes), PWV (pulse-wave velocity)Keywords
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Article info
Publication history
Published online: September 17, 2012
Accepted:
July 23,
2012
Received:
April 17,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
