Abstract
Background
The risk of cardiovascular diseases is lower among moderate alcohol drinkers than
among both nondrinkers and heavy drinkers. However, factors that can account for the
U-shaped or J-shaped relationship between daily alcohol consumption and incident cardiovascular
diseases remain obscure.
Purpose
The present cross-sectional study investigated the relationship between alcohol consumption
and serum adiponectin levels.
Method
Total adiponectin was measured in 527 males participating in health check-up programs
(age range 40–86 years, mean 60.5 years). Based on questionnaire responses, alcohol
intake was categorized into three groups: none or occasional (A1); <50 g/day and ≥3 days/week (A2); and ≥50 g/day and ≥3 days/week (A3).
Results
No significant differences in adiponectin levels were observed among the three alcohol
consumption groups of subjects without the metabolic syndrome (MetS). In subjects
with the MetS, the adiponectin level was significantly higher in the A2 (moderate
drinker) group than in both the A1 and A3 groups. MetS subjects in group A2 had higher
HDL-C levels than those in A1, but levels in group A3 were not significantly different
from those in group A2.
Conclusion
An increased adiponectin level in moderate alcohol drinkers who have MetS may contribute
to the U-shaped relationship between alcohol consumption and risk of cardiovascular
events, in addition to the involvement of HDL-C.
Abbreviations:
HDL-C (high-density lipoprotein cholesterol), MetS (metabolic syndrome), EDTA (ethylene diamine tetra acetic acid), IRI (immunoreactive insulin), CVs (coefficients of variation), ELISA (enzyme-linked immunosorbent assay), HOMA-IR (homeostasis model assessment of insulin resistance), eGFR (estimated glomerular filtration rate), HbA1c (glycosylated hemoglobin), HPLC (high performance liquid chromatography), JDS (Japan Diabetes Society), NGSP (National Glycohemoglobin Standardization Program), sBP (systolic blood pressure), dBP (diastolic blood pressure), LDL-C (low-density lipoprotein cholesterol), CRP (C-reactive protein)Keywords
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Article info
Publication history
Published online: October 02, 2012
Accepted:
September 4,
2012
Received:
June 20,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
