Abstract
Objective
To examine maternal serum levels of retinol-binding protein-4 (RBP4) at 11–13 weeks’ gestation in normal and pathological pregnancies.
Methods
Serum RBP4 at 11–13 weeks was measured in 480 singleton pregnancies, including 240 with normal outcome,
60 that subsequently developed preeclampsia (PE), 60 that developed gestational diabetes
mellitus (GDM), 60 that delivered large for gestational age (LGA) neonates and 60
that delivered small (SGA) neonates. The values in each adverse pregnancy outcome
group were compared to those of normal pregnancies.
Results
Serum concentration of RBP4 was not significantly different in women who subsequently
developed PE (p=0.925), or GDM (p=0.074), or had pregnancies that led to delivery to SGA (p=0.085), LGA (p=0.332) neonates.
Conclusion
Maternal serum RBP4 in the first trimester is not significantly altered in pathological
pregnancies.
Abbreviations:
AGA (Appropriate for gestational age), β-HCG (β-Human Chorionic Gonadotrophin), CRL (Crown-rump length), CV (Coefficient of Variation), ELISA (Enzyme-linked Immunosorbent Assay), EIA (Enzyme Immunometric Assay), GDM (Gestational Diabetes Mellitus), LGA (Large for gestational age), MoM (Multiples of Median), NT (Nuchal Translucency), PAPP-A (Pregnancy-associated Plasma Protein A), PE (Preeclampsia), RBP4 (Retinol binding protein-4), SGA (Small for gestational age), T2DM (Type 2 diabetes mellitus)Keywords
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Article info
Publication history
Published online: February 13, 2013
Accepted:
December 13,
2012
Received:
August 12,
2012
Footnotes
Details of ethics approval: Ethical approval was granted by the NHS National Research Ethics Service (02-03-033).
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
