Abstract
Background and Aims
The metabolic syndrome (MetS) is a common and complex disorder that consists of various
abnormalities, including dyslipidemia, obesity, hypertension and hyperglycemia. We
investigated the relationships between the levels of advanced protein oxidation products
(AOPPs), the total antioxidant capacity (TAC) and the pro-oxidant-antioxidant balance
(PAB) in MetS patients.
Methods
A total of 55 patients (37 women, 18 men) with MetS and 20 healthy controls (14 women,
6 men) with a body mass index (BMI) less than 25 kg/m2 were enrolled in the study. Colorimetric methods were used to determine the levels
of AOPPs, the TAC, and the PAB.
Results
AOPP, TAC, and PAB values were significantly higher in patients with MetS than in
control subjects (p<0.001, p=0.050, and p<0.001, respectively). A positive correlation was observed between the AOPP levels
and the glucose, triglyceride, insulin and HOMA-IR levels. PAB values also exhibited
significant positive correlations with diastolic blood pressure and fibrinogen levels.
Logistic regression analysis revealed that higher serum PAB values were positively
and independently associated with the MetS (odds ratio: 1.110; 95% confidence interval:
1.006–1.224; P<0.37).
Conclusions
Increased AOPP levels and higher PAB values are likely to be a result of oxidative
stress, a condition in which an imbalance occurs between the production and inactivation
of reactive oxygen species. In addition, it appears that serum PAB values may accurately
reflect the levels of oxidative stress in MetS patients.
Abbreviations:
MetS (metabolic syndrome), AOPP (advanced protein oxidation products), TAC (total antioxidant capacity), PAB (pro-oxidant antioxidant balance), CAD (coronary artery disease), BMI (body mass index), AUC (area under the curve), HOMA (homeostasis model assessment), IR (insulin resistance), NAFLD (non-alcoholic fatty-liver disease), ROS (reactive oxygen species), FRAP (ferric reducing antioxidant power), HDL-C (high density lipoprotein-cholesterol), ROC (receiver operating characteristic), ORAC (oxygen radical absorbance capacity), RAS (renin–angiotensin system)Keywords
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Article info
Publication history
Published online: February 13, 2013
Accepted:
January 3,
2013
Received:
October 23,
2012
Identification
Copyright
© 2013 Published by Elsevier Inc. All rights reserved.
