Abstract
Objective
Fuel oxidation during exercise was studied in type 1 insulin-dependent (T1DM) patients
mainly under quite constant insulin and glycemia; these protocols, however, likely
do not reflect patients’ usual metabolic conditions. The glucose oxidation rate (GLUox)
in T1DM patients under usual life conditions was thus investigated during prolonged
exercise (3-h) and its behavior was described mathematically.
Materials/Methods
Whole-body GLUox was determined in eight T1DM patients (4/8 M; aged 35–59 years) and eight well-matched healthy subjects. Venous blood was drawn prior to and
every 30 min until the end of exercise; glycemia, insulin, cortisol, and growth hormone concentrations
were determined. Oxygen consumption, carbon dioxide production, and ventilation were
measured at rest and thereafter every 30 min of the exercise. To prevent hypoglycemia, patients were given fruit fudge (93%
sucrose) prior to / during exercise.
Results
Insulin concentration and glycemia were significantly higher in patients across the
entire exercise period (group effect, p<0.001 for both). GLUox decreased significantly with increasing exercise duration (time
effect, p<0.001), but no significant difference was detected between the two groups (group effect,
p=NS). GLUox, expressed as the percentage of the starting value, was described by an
exponential function showing a time constant of 90 min (n=96; mean corrected R2=0.666).
Conclusions
GLUox in T1DM patients was not significantly different from the rate observed in the
control subjects. The function describing the time course of GLUox may be useful to
correct an estimated GLUox for the duration of exercise and help T1DM patients avoiding
exercise-induced glycemic imbalances.
Abbreviations:
CGM (Continuous Glucose Monitoring device), CHO (Carbohydrates), GLUox (Glucose oxidation rate), hGH (Growth hormone), HR (Heart Rate), HRmax (Theoretical maximal heart rate calculated as 220 − age (expressed in years)), HRrest (Resting heart rate), HRtarget (Target heart rate during the trials), IU (Insulin Units), RER (Respiratory exchange ratio), T1DM (Type 1 insulin-dependent diabetes), V˙CO2 (Carbon dioxide production), V˙O2 (Oxygen consumption)Keywords
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Article info
Publication history
Published online: February 04, 2013
Accepted:
January 1,
2013
Received:
July 20,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
