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Clinical Science| Volume 62, ISSUE 6, P845-850, June 2013

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Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects

  • Chan Joo Lee
    Affiliations
    Department of Biochemistry and Molecular Biology, Institute of Genetic Science, Integrated Genomic Research Center for Metabolic Regulation, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Yong-ho Lee
    Affiliations
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Sahng Wook Park
    Affiliations
    Department of Biochemistry and Molecular Biology, Institute of Genetic Science, Integrated Genomic Research Center for Metabolic Regulation, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Kwang Joon Kim
    Affiliations
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Sungha Park
    Correspondence
    Corresponding author. Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea. Tel.: +82 2 2228 8455; fax: +82 2 393 2041.
    Affiliations
    Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Cardiovascular Genome Center, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Jong-Chan Youn
    Affiliations
    Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Sang-Hak Lee
    Affiliations
    Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Seok-Min Kang
    Affiliations
    Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Yangsoo Jang
    Affiliations
    Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Cardiovascular Genome Center, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
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Published:February 04, 2013DOI:https://doi.org/10.1016/j.metabol.2013.01.005

      Abstract

      Objective

      The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients.

      Methods

      A total of 126 hypertensive patients over the age of 45 were enrolled. The maximum carotid IMT (max-IMT) and the mean carotid IMT (mean-IMT) were measured at the time of enrollment. Clinical and laboratory parameters including serum PCSK9 were analyzed.

      Results

      Patients were divided into tertiles based on serum PCSK9 levels. After adjusting for age, sex, total cholesterol, HDL-cholesterol and triglyceride, max-IMT was significantly increased in the highest tertile of serum PCSK9 (0.969±0.033 vs 0.959±0.033 vs 1.077±0.033 mm, respectively; P=0.026). Mean-IMT showed a tendency to increase across the tertile groups (0.773±0.025 vs 0.790±0.026 vs 0.856±0.025 mm, respectively; P=0.059). Multivariate regression analysis revealed that serum PCSK9 was independently associated with carotid IMT (max-IMT: β=0.212, P=0.016; mean-IMT: β=0.184, P=0.04).

      Conclusion

      The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis.

      Abbreviations:

      ANCOVA (analysis of covariance), ANOVA (analysis of variance), SD (standard deviation), BMI (body mass index), SBP (systolic blood pressure), DBP (diastolic blood pressure), DM (diabetes mellitus), IMT (intima media thickness), LDLR (low-density lipoprotein receptor), PCSK9 (proprotein convertase subtilisin/kexin type 9)

      Keywords

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