Irisin is a newly discovered myokine suggested to mediate some of the beneficial effects
of exercise. Bostrom et al. initially reported a significant increase in muscle expression
of type I membrane protein fibronectin type III domain containing 5 (FNDC5) in mice
overexpressing muscle-specific PPAR-g co-activator-1a (PGC1a) [
[1]
]. Furthermore, FNDC5 was cleaved and secreted as irisin in circulation and induced
browning of subcutaneous adipose tissues via elevation of uncoupling protein 1. Recent
findings also revealed that circulating irisin is increased in a transient manner
by an acute bout of exercise, its concentration correlates with the intensity of exercise,
and stimulation of cultured human cells with exogenous irisin results in regulation
of not only adipocyte browning but also muscle growth and metabolism [
1
,
2
,
3
]. Since exercise is a major strategy to reduce body weight, increase energy expenditure
and ameliorate metabolic dysfunctions, irisin has been considered a potential therapeutic
candidate to mimic the physiological effects of exercise and hence treat metabolic
diseases.Abbreviations:
FNDC5 (fibronectin type III domain containing 5), PGC1a (PPAR-g co-activator-1a), T2DM (type 2 diabetes), CK (creatinine kinase)Keyword
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Article info
Publication history
Published online: April 08, 2015
Accepted:
February 25,
2015
Received:
February 9,
2015
Identification
Copyright
© 2015 Published by Elsevier Inc.
