Advances at the intersection of sleep and metabolism research

      In this curated special issue of Metabolism, we focus on the associations between sleep and metabolism featuring review articles by worldwide leading experts in the field. Sleep is critical to human life and wellbeing. Sleep is a time of restoration and rejuvenation that is essential to a number of human biological systems, including brain function, immune response, and metabolism; thus, we spend a great deal of time asleep- around a third of our lives. Insufficient and/or poor quality sleep has been linked to obesity, diabetes, and cardiovascular disease [
      • Nedeltcheva A.V.
      • Scheer F.A.
      Metabolic effects of sleep disruption, links to obesity and diabetes.
      ,
      • Patel S.R.
      • Hayes A.L.
      • Blackwell T.
      • Evans D.S.
      • Ancoli-Israel S.
      • Wing Y.K.
      • et al.
      The association between sleep patterns and obesity in older adults.
      ,
      • Wu Y.
      • Zhai L.
      • Zhang D.
      Sleep duration and obesity among adults: a meta-analysis of prospective studies.
      ,
      • Faraut B.
      • Boudjeltia K.Z.
      • Vanhamme L.
      • Kerkhofs M.
      Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery.
      ,
      • Reitz C.J.
      • Martino T.A.
      Disruption of circadian rhythms and sleep on critical illness and the impact on cardiovascular events.
      ,
      • Tobaldini E.
      • Pecis M.
      • Montano N.
      Effects of acute and chronic sleep deprivation on cardiovascular regulation.
      ]. Although information about these connections has been rapidly growing over the past few years, the field is still in need of treatments that can address both the sleep disorder and the resultant metabolic dysfunctions. In this issue, we highlight the state of the field in terms of research about sleep and metabolism connections as well as current therapies.
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