Advertisement
Editorial| Volume 92, P1-5, March 2019

Download started.

Ok

Obesity: seize the day, fight the fat

Published:January 06, 2019DOI:https://doi.org/10.1016/j.metabol.2018.12.011
      Obesity is the global epidemic of the 21st century: about 1.5 billion adults worldwide are overweight, and among them, about 200 million men and 300 million women are obese [
      • Finucane M.M.
      • Stevens G.A.
      • Cowan M.J.
      • Danaei G.
      • Lin J.K.
      • Paciorek C.J.
      • et al.
      National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants.
      ]. In some countries, the prevalence of obesity has exceeded 50%, as in Tonga (men), and in Kuwait, Kiribati, Micronesia, Libya, Qatar, Tonga and Samoa (women) [
      • Ng M.
      • Fleming T.
      • Robinson M.
      • Thomson B.
      • Graetz N.
      • Margono C.
      • et al.
      Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the global burden of disease study 2013.
      ]. The prevalence of overweight and obesity are also increasing in children and adolescents in developed (about 25%) and in developing countries (about 13%) [
      • Ng M.
      • Fleming T.
      • Robinson M.
      • Thomson B.
      • Graetz N.
      • Margono C.
      • et al.
      Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the global burden of disease study 2013.
      ]. Obesity has been associated with many comorbidities, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), hypertension, chronic kidney disease, cardiovascular disease (CVD), and malignancies, leading to increased mortality observed in obese individuals [
      • Global BMIMC
      • Di Angelantonio E.
      • Bhupathiraju Sh N.
      • Wormser D.
      • Gao P.
      • Kaptoge S.
      • et al.
      Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.
      ]. Overweight and obesity were estimated to be associated worldwide with 3.4 million deaths, which could also be expressed as 4% of disability-adjusted life-years lost (DALYs) [
      • Lim S.S.
      • Vos T.
      • Flaxman A.D.
      • Danaei G.
      • Shibuya K.
      • Adair-Rohani H.
      • et al.
      A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010.
      ]. It is also alarming that children with severe obesity are apparently at increased risk of premature death [
      • Bass R.
      • Eneli I.
      Severe childhood obesity: an under-recognised and growing health problem.
      ].

      Keywords

      Abbreviations:

      ABOM (American Board of Obesity Medicine), ACA (American College of Cardiology), AHA (American Heart Association), BMI (body mass index), CVD (cardiovascular disease), DALYs (disability-adjusted life-years), GLP (glucagon-like peptide), MHO (metabolically healthy obesity), MUO (metabolically unhealthy obesity), NAFLD (nonalcoholic fatty liver disease), NASH (nonalcoholic steatohepatitis), OMEC (Obesity Medicine Education Collaborative), PCOS (polycystic ovary syndrome), PCSK (proprotein convertase subtilisin/kexin type), SCOPE (Strategic Centre for Obesity Professional Education), SGLT (sodium-glucose cotransporter), T2DM (type 2 diabetes mellitus), TOS (The Obesity Society), WHO (World Health Organization)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Metabolism - Clinical and Experimental
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Finucane M.M.
        • Stevens G.A.
        • Cowan M.J.
        • Danaei G.
        • Lin J.K.
        • Paciorek C.J.
        • et al.
        National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants.
        Lancet. 2011; 377: 557-567
        • Ng M.
        • Fleming T.
        • Robinson M.
        • Thomson B.
        • Graetz N.
        • Margono C.
        • et al.
        Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the global burden of disease study 2013.
        Lancet. 2014; 384: 766-781
        • Global BMIMC
        • Di Angelantonio E.
        • Bhupathiraju Sh N.
        • Wormser D.
        • Gao P.
        • Kaptoge S.
        • et al.
        Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.
        Lancet. 2016; 388: 776-786
        • Lim S.S.
        • Vos T.
        • Flaxman A.D.
        • Danaei G.
        • Shibuya K.
        • Adair-Rohani H.
        • et al.
        A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010.
        Lancet. 2012; 380: 2224-2260
        • Bass R.
        • Eneli I.
        Severe childhood obesity: an under-recognised and growing health problem.
        Postgrad Med J. 2015; 91: 639-645
        • Ma C.
        • Avenell A.
        • Bolland M.
        • Hudson J.
        • Stewart F.
        • Robertson C.
        • et al.
        Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis.
        BMJ. 2017; 359: j4849
        • Withrow D.
        • Alter D.A.
        The economic burden of obesity worldwide: a systematic review of the direct costs of obesity.
        Obes Rev. 2011; 12: 131-141
        • Wang Y.
        • Beydoun M.A.
        • Liang L.
        • Caballero B.
        • Kumanyika S.K.
        Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic.
        Obesity (Silver Spring). 2008; 16: 2323-2330
        • Chooi Y.C.
        • Ding C.
        • Magkos F.
        The epidemiology of obesity.
        Metabolism. 2018; 92: 6-10
        • Chapelot D.
        • Charlot K.
        Physiology of energy homeostasis: models, actors, challenges and the glucoadipostatic loop.
        Metabolism. 2018; 92: 11-25
        • Oussaada S.M.
        • van Galen K.A.
        • Cooiman M.I.
        • Kleinendorst L.
        • Hazebroek E.J.
        • van Haelst M.M.
        • et al.
        The pathogenesis of obesity.
        Metabolism. 2019; 92: 26-36
        • Rohde K.
        • Keller M.
        • la Cour Poulsen L.
        • Bluher M.
        • Kovacs P.
        • Bottcher Y.
        Genetics and epigenetics in obesity.
        Metabolism. 2018; 92: 37-50
        • Iacobini C.
        • Pugliese G.
        • Blasetti Fantauzzi C.
        • Federici M.
        • Menini S.
        Metabolically healthy versus metabolically unhealthy obesity.
        Metabolism. 2018; 92: 51-60
        • Nimptsch K.
        • Konigorski S.
        • Pischon T.
        Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine.
        Metabolism. 2019; 92: 61-70
        • Vekic J.
        • Zeljkovic A.
        • Stefanovic A.
        • Jelic-Ivanovic Z.
        • Spasojevic-Kalimanovska V.
        Obesity and dyslipidemia.
        Metabolism. 2018; 92: 71-81
        • Polyzos S.A.
        • Kountouras J.
        • Mantzoros C.S.
        Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics.
        Metabolism. 2018; 92: 82-97
        • Koliaki C.
        • Liatis S.
        • Kokkinos A.
        Obesity and cardiovascular disease: revisiting an old relationship.
        Metabolism. 2018; 92: 98-107
        • Glueck C.J.
        • Goldenberg N.
        Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics.
        Metabolism. 2018; : 108-120
        • Avgerinos K.I.
        • Spyrou N.
        • Mantzoros C.S.
        • Dalamaga M.
        Obesity and Cancer risk: emerging biological mechanisms and perspectives.
        Metabolism. 2018; 92: 121-135
        • Suarez A.L.
        Burden of cancer attributable to obesity, type 2 diabetes and associated risk factors.
        Metabolism. 2018; 92: 136-146
        • Weihrauch-Bluher S.
        • Schwarz P.
        • Klusmann J.H.
        Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood.
        Metabolism. 2018; 92: 147-152
        • Yannakoulia M.
        • Poulimeneas D.
        • Mamalaki E.
        • Anastasiou C.A.
        Dietary modifications for weight loss and weight loss maintenance.
        Metabolism. 2019; 92: 153-163
        • Jensen M.D.
        • Ryan D.H.
        • Apovian C.M.
        • Ard J.D.
        • Comuzzie A.G.
        • Donato K.A.
        • et al.
        2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the Obesity Society.
        Circulation. 2014; 129: S102-S138
        • Jacobs Jr., D.R.
        • Petersen K.S.
        • Svendsen K.
        • Ros E.
        • Sloan C.B.
        • Steffen L.M.
        • et al.
        Considerations to facilitate a US study that replicates PREDIMED.
        Metabolism. 2018; 85: 361-367
        • Petridou A.
        • Siopi A.
        • Mougios V.
        Exercise in the management of obesity.
        Metabolism. 2018; 92: 163-169
        • Pilitsi E.
        • Farr O.M.
        • Polyzos S.A.
        • Perakakis N.
        • Nolen-Doerr E.
        • Papathanasiou A.E.
        • et al.
        Pharmacotherapy of obesity: available medications and drugs under investigation.
        Metabolism. 2018; : 170-192
        • Bassatne A.
        • Chakhtoura M.
        • Saad R.
        • El-Hajj Fuleihan G.
        Vitamin D supplementation in obesity and during weight loss: a review of randomized controlled trials.
        Metabolism. 2019; 92: 193-205
        • Holick M.F.
        • Binkley N.C.
        • Bischoff-Ferrari H.A.
        • Gordon C.M.
        • Hanley D.A.
        • Heaney R.P.
        • et al.
        Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.
        J Clin Endocrinol Metab. 2011; 96: 1911-1930
        • Nudel J.
        • Sanchez V.M.
        Surgical management of obesity.
        Metabolism. 2018; : 206-216
        • Phillips B.T.
        • Shikora S.A.
        The history of metabolic and bariatric surgery: development of standards for patient safety and efficacy.
        Metabolism. 2018; 79: 97-107
        • Geserick M.
        • Vogel M.
        • Gausche R.
        • Lipek T.
        • Spielau U.
        • Keller E.
        • et al.
        Acceleration of BMI in early childhood and risk of sustained obesity.
        N Engl J Med. 2018; 379: 1303-1312
        • Apovian C.M.
        • Aronne L.J.
        • Bessesen D.H.
        • McDonnell M.E.
        • Murad M.H.
        • Pagotto U.
        • et al.
        Pharmacological management of obesity: an endocrine society clinical practice guideline.
        J Clin Endocrinol Metab. 2015; 100: 342-362
        • Davies M.J.
        • D'Alessio D.A.
        • Fradkin J.
        • Kernan W.N.
        • Mathieu C.
        • Mingrone G.
        • et al.
        Management of Hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of diabetes (EASD).
        Diabetes Care. 2018; 41: 2669-2701
        • Gortmaker S.L.
        • Swinburn B.A.
        • Levy D.
        • Carter R.
        • Mabry P.L.
        • Finegood D.T.
        • et al.
        Changing the future of obesity: science, policy, and action.
        Lancet. 2011; 378: 838-847
        • Green A.M.
        • Innes-Hughes C.
        • Rissel C.
        • Mitchell J.
        • Milat A.J.
        • Williams M.
        • et al.
        Codesign of the population health information management system to measure reach and practice change of childhood obesity programs.
        Public Health Res Pract. 2018; 28
        • Behrens T.K.
        • Liebert M.L.
        • Peterson H.J.
        • Howard Smith J.
        • Sutliffe J.T.
        • Day A.
        • et al.
        Changes in school food preparation methods result in healthier cafeteria lunches in elementary schools.
        Am J Prev Med. 2018; 54: S139-S144
        • Shi Y.
        • Grech A.L.
        • Allman-Farinelli M.
        Changes in the nutritional quality of products sold in university vending machines since implementation of the health star rating in 2014; an environmental audit.
        BMC Public Health. 2018; 18: 1255
        • Hamet P.
        • Tremblay J.
        Artificial intelligence in medicine.
        Metabolism. 2017; 69s: S36-S40