Oxidative Stress Mediated Diabetes and Associated Metabolic Malfunctions Abrogation by Melatonin and Extract of Menthalongifolia (L.) in Insulin Resistant Diabetic Rats

      Insulin resistance hyperglycemia involves interplay of oxidative imbalance through favoring the production of free radicals and reduction of antioxidant defenses. Synthetic drugs that have anti- diabetic as well as anti-oxidant activity are used against diabetes but showing diverse range of side effects. Medicinal plants extracts have been used successfully since ancient time to treat diabetes and its complications. New research is required to screen and elucidate potential natural extracts with reduced side effects in treating diabetes and associated metabolic complications of liver. The present study was conducted to investigate the beneficial effects of melatonin and methanolic extract of MenthaLongifolia (L.) against alloxan induced oxidative stress allied insulin resistant diabetes. In the present study administration of melatonin (10 mg/kg body weight) and extract of Menthalongifolia (L.) (200 mg/kg body weight) were given for 15 days to evaluate their effect on serum glucose, reactive oxygen species (ROS), superoxide dismutase (SOD), catalase (CAT), total cholesterol, triglycerides, alanine amino transferase (ALT) and aspartate amino transferase (AST) in normal and Insulin-resitant diabetic rats. Alloxan significantly altered ROS level, SOD and CAT activities accompanied by changes in AST and ALT levels. However, these parameters were normalized by melatonin administration. Interestingly Menthalongifolia(L.) was noted to alleviate hyperglycemic condition and significantly reduced the ROS levels, normalized the anti-oxidants as well as modulate the elevated lipid profile and liver enzyme status of insulin resistant diabetic rats. Thus, it is suggested that co administration of melatonin and Menthalongifolia (L.) can possess substantial therapeutic potential against insulin resistant diabetes linked metabolic complications.
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