Background: Genome wide association studies shows SORT1 expression to affect lipid metabolism and thus identifies it as a risk gene for coronary artery disease (CAD). Higher circulating levels of Sortilin in patients with atherosclerosis is reported. However very little is known about its expression in patients with CAD. In hepatocytes, Sortilin interacts with PCSK9 in Trans Golgi network and helps its secretion from liver. In macrophages, Sortilin promotes LDL uptake, form cell formation and atherosclerosis.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Metabolism - Clinical and Experimental
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect