Evaluation of the effect of β-Caryophyllene on oxidative stress in BALB / c mice with streptozotocin-induced diabetes

Background. Type 2 diabetes mellitus (T2DM) is a disease characterized by hyperglycemia, hyperlipidemia, and organic insulin resistance. This pathological change in circulating energy levels and the utilization of the energy substrate by central and peripheral tissues contributes to mitochondrial dysfunction where critical cellular pathways such as energy substrate metabolism and reactive oxygen species (ROS) take place. β-caryophyllene (BCP) is an isolated natural bicyclic sesquiterpene, it is a selective agonist of the cannabinoid receptor type 2 (CB2R), which is mainly expressed in the peripheral nervous system. The antioxidant mechanism of β-caryophyllene is linked to its structure since it has double rings, which allows the insertion of free radicals, avoiding the deterioration of the oxidant/antioxidant state. Objective. The present work aimed to evaluate the effect of β-caryophyllene on oxidative stress in a murine model after streptozotocin administration. Methods. BALB / c mice were used to which streptozotocin was administered, as well as β-caryophyllene and glucose levels, catalaza activity, oxidized lipids and nitric oxide levels were determined. Results. Glucose levels, catalaza activity, and oxidized lipids in the group that was only administered STZ showed a significant increase, while the group that was administered β-caryophyllene significantly decreased glucose levels, as well as oxidized lipids and nitric oxide, on the other hand, catalase activity decreased but was not significant. Conclusion. The β-caryophyllene has an antioxidant effect in reducing the oxidized lipids as well as the nitric oxide generated after the administration of streptozotocin.