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Research Article| Volume 14, ISSUE 12, P1267-1272, December 1965

Uric acid excretion and ketosis in fasting

  • Author Footnotes
    a From New England Medical Center Hospitals and the Department of Medicine, TuftsUniversity School of Medicine, Boston, Massachusetts.
    ,
    Author Footnotes
    b Philip N. Cheifetz, M.D.: Medical Research Fellow, Medical Research Council, Canada.
    Philip N. Cheifetz
    Footnotes
    a From New England Medical Center Hospitals and the Department of Medicine, TuftsUniversity School of Medicine, Boston, Massachusetts.
    b Philip N. Cheifetz, M.D.: Medical Research Fellow, Medical Research Council, Canada.
    Search for articles by this author
  • Author Footnotes
    a From New England Medical Center Hospitals and the Department of Medicine, TuftsUniversity School of Medicine, Boston, Massachusetts.
    b Philip N. Cheifetz, M.D.: Medical Research Fellow, Medical Research Council, Canada.
DOI:https://doi.org/10.1016/S0026-0495(65)80006-3
Uric acid excretion and ketosis in fasting
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      The clearance of uric acid, of total ketones,and of creatinine was determined during a 10-day fast in 4 obese women and in response to an acute infusion of β-hydroxybutyrate. A brisk fall followed by a plateau of uric acid clearance was concomitant with a steady rise of plasma ketones; thereafter the changes were not uniform. This inverse relationship in the early stages of fasting was duplicated with exogenous ketosis. The inhibition of renal excretion of uric acid by the ketosis of fasting is confirmed and some mechanisms for this effect are suggested.
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      Article info

      Publication history

      Received: July 23, 1965

      Footnotes

      *This investigation was performed on the Clinical Study Unit of the New England Medical Center Hospitals U.S.P.H.S., M01-FR-54, and was supported by Grants 2A-5166 and A-612 from the National Institutes of Health, Bethesda, Maryland.

      Identification

      DOI: https://doi.org/10.1016/S0026-0495(65)80006-3

      Copyright

      © 1965 Published by Elsevier Inc.

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