The effects of starvation, high fat diets, and ketone infusions on uric acid balance

  • Author Footnotes
    1 From the Department of Medicine and the Metabolic Unit of the Wilford Hall USAF Hospital, Aerospace Medical Division, Air Force Systems Command, Lackland Air Force Base, Texas.
    Frank R. Lecocq
    Footnotes
    1 From the Department of Medicine and the Metabolic Unit of the Wilford Hall USAF Hospital, Aerospace Medical Division, Air Force Systems Command, Lackland Air Force Base, Texas.
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  • Author Footnotes
    1 From the Department of Medicine and the Metabolic Unit of the Wilford Hall USAF Hospital, Aerospace Medical Division, Air Force Systems Command, Lackland Air Force Base, Texas.
    John J. McPhaul Jr.
    Footnotes
    1 From the Department of Medicine and the Metabolic Unit of the Wilford Hall USAF Hospital, Aerospace Medical Division, Air Force Systems Command, Lackland Air Force Base, Texas.
    Search for articles by this author
  • Author Footnotes
    1 From the Department of Medicine and the Metabolic Unit of the Wilford Hall USAF Hospital, Aerospace Medical Division, Air Force Systems Command, Lackland Air Force Base, Texas.
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      Studies of factors arising during fasting which could influence uric acid excretion were carried out in 15 patients. Potassium supplementation and alkalinization did not influence the decreased urinary excretion of uric acid found during fasting, whereas probenecid and glucose administration effected a prompt uricosuria. Glomerular filtration rate was not altered by 7 days of fasting, but changes in uric acid balance appeared to be related to changes in ketone concentrations. The effect of ketosis in the absence of fasting was studied by feeding high fat diets in 6 subjects and ketone infusions in 5 others. In both groups uric acid clearance was depressed. It is postulated that ketones compete with uric acid for a common tubular secretory site, the magnitude of the changes in ketones precluding normal uric acid secretion.
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