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Abstract
From a total of 12 pairs of young male identical twins who were overfed by an estimated
84,000 kcal over a period of 100 days, several pairs (eight to 11, depending on variables)
were remeasured for body weight, body composition with the underwater weighing technique,
regional fat distribution from skinfolds, girths, computed tomography (CT) fat areas
in the abdominal region, and fasting plasma glucose, insulin, total cholesterol, high-density
lipoprotein (HDL) cholesterol, and triglycerides 4 months and 5 years after completion
of the overfeeding protocol. At 4 months, the twins had lost approximately 7 of 8
kg that they had gained with overfeeding. However, 5 years later, body weight had
increased by 5 kg over the preoverfeeding level. Fluctuations in fat mass were greater
than those in fat-free mass. The younger twins gained approximately twice as much
as the older twins in the late recovery period, a difference attributed to the late
phase of growth in body mass in the former. Upper-body fat was reduced at 4 months
of follow-up study, but was increased in the late recovery phase. All blood values
were normalized in the postoverfeeding periods. A within-pair resemblance was generally
observed for the changes noted in the recovery periods, but it was more striking when
variations between preoverfeeding and 4-month or 5-year values were considered. We
conclude from these observations that there were no persistent effects of exposure
to the overfeeding protocol over the expected age-associated increases in body mass,
body fat, upper-body fat, abdominal visceral fat (AVF), and metabolic variables predictive
of risk for common diseases in individuals of normal body weight and with no family
history of obesity. The intrapair resemblance suggests that the genotype contributes
to the alterations observed in the recovery from overfeeding and in the age-associated
changes.
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Article info
Publication history
Accepted:
March 12,
1996
Received:
November 27,
1995
Footnotes
☆Supported in part by grants from the National Institutes of Health (DK-34624) and the Medical Research Council of Canada (PG11811 and MA10499).
Identification
Copyright
© 1996 Published by Elsevier Inc.